CAJ | 학술논문

目的：探讨乳腺癌中的HER-2的表达及意义，研究患者的腋窝淋巴结转移、TNM分期、组织学类型、PR和ER间的关系以及HER-2过度表达的药物治疗策略。方法选择该院2008年5月至2012年5月收治的确诊为乳腺癌的84例患者，对这84例患者进行检查，并将其病情分类，应用免疫组织化学（S P ）法对其进行检测，将结果与正常乳腺组织的样本进行对照。结果乳腺癌患者乳腺组织内的 HER-2因子受体要高于正常的乳腺组织，差异有统计学意义（P＜0．05），患者乳腺癌组织中 HER-2受体的表达与其TNM分期、组织学类型无关（P＝0．256、0．157）。结论 HER-2在乳腺癌的发生发展中起关键作用，能够为乳腺癌患者的诊断、多靶向治疗提供依据。
목적：탐토유선암중적HER-2적표체급의의，연구환자적액와림파결전이、TNM분기、조직학류형、PR화ER간적관계이급HER-2과도표체적약물치료책략。방법선택해원2008년5월지2012년5월수치적학진위유선암적84례환자，대저84례환자진행검사，병장기병정분류，응용면역조직화학（S P ）법대기진행검측，장결과여정상유선조직적양본진행대조。결과유선암환자유선조직내적 HER-2인자수체요고우정상적유선조직，차이유통계학의의（P＜0．05），환자유선암조직중 HER-2수체적표체여기TNM분기、조직학류형무관（P＝0．256、0．157）。결론 HER-2재유선암적발생발전중기관건작용，능구위유선암환자적진단、다파향치료제공의거。
Objective To study the expression of HER-2 expression in breast cancer and the significance ,and to look into rela-tions between axillary lymph node metastasis in patients ,TNM ,T staging ,histological type ,PR and ER as well as drug treatment strategy of HER-2 over expression .Methods Eighty-four cases of patients admitted by this hospital from May 2008 to May 2012 diagnosed with breast cancers were selected ,84 patients were examined in this hospital ,and conditions of patients were classified , they were tested by use of Streptavidin-Peroxidase (SP method) ,test results and samples of normal breast tissues were compared . Results The level of HER-2 factor receptor in mammary gland tissues of patients with breast cancer was higher than that within normal breast tissue ,the difference was statistically significant (P< 0 .05) ,the expression of HER-2 receptor in patients with breast cancer tissue was unrelated to TNM staging ,histological type (P values were 0 .256 and 0 .157 respectively) .Conclusion HER-2 plays a key role in the identifying the generation and development of the breast cancer ,and it can provide the basis for the diagnosis ,multi-targeted therapy of patients with breast cancers .