CAJ | 학술논문

目的探讨血管肉瘤的临床特点及疗效.方法回顾性分析2004年1月至2012年3月收治的血管肉瘤患者的临床资料,对肿瘤的临床表现、治疗方法和结果进行观察.结果 7例患者,男4例,女3例,中位年龄67岁(37 ～ 77岁).7例患者中,不规则结节样肿块伴破溃4例,局部溃疡1例,红色不规则结节2例.入院后均予手术治疗,部分患者予术后辅助治疗.术后组织病理见肿瘤细胞分化程度不同,有异形,内皮细胞明显增生,均诊断为头皮原发的血管肉瘤.免疫组化:CD31、CD34均阳性.术后4例复发,首次复发中位时间为3.5个月(1～6个月),1例5个月后发现脑组织转移,2例死亡.结论血管肉瘤是少见的恶性肿瘤,临床表现多变,局部广泛切除为治疗的基础,辅助治疗对改善其预后起到积极的作用.
목적 탐토혈관육류적림상특점급료효.방법 회고성분석2004년1월지2012년3월수치적혈관육류환자적림상자료,대종류적림상표현、치료방법화결과진행관찰.결과 7례환자,남4례,녀3례,중위년령67세(37 ～ 77세).7례환자중,불규칙결절양종괴반파궤4례,국부궤양1례,홍색불규칙결절2례.입원후균여수술치료,부분환자여술후보조치료.술후조직병리견종류세포분화정도불동,유이형,내피세포명현증생,균진단위두피원발적혈관육류.면역조화:CD31、CD34균양성.술후4례복발,수차복발중위시간위3.5개월(1～6개월),1례5개월후발현뇌조직전이,2례사망.결론 혈관육류시소견적악성종류,림상표현다변,국부엄범절제위치료적기출,보조치료대개선기예후기도적겁적작용.
Objective To assess clinical features and treatment of angiosarcoma.Methods A retrospective study was carried out among seven patients hospitalized for angiosarcoma in the Department of Plastic Surgery,Zhongshan Hospital of Fudan University from January 2004 to March 2012.Clinical behaviors,therapeutic strategies and outcomes of angiosarcoma were analyzed in these patients.Results Of the seven patients,four were male,and three were female,with a median age of 67 years (range,37-77 years).Clinical presentations were various,including irregular ulcerous nodular masses in four patients,localized ulcer in one patient,and irregular erythematous nodules in two patients.All the patients were treated surgically with or without postoperative adjuvant therapy.Pathological examination revealed various degrees of differentiation and atypia of tumor cells,as well as obvious proliferation of endothelial cells,and all of these patients were diagnosed as angiosarcoma.Immunohistochemical analysis revealed a positive staining for CD31 and CD34.After surgical treatment,angiosarcoma recurred in four patients with the median time to the first recurrence being 3.5 months (range,1-6 months),cerebral metastasis occurred in one patient 5 months later,and two patients died.Conclusions Angiosarcoma is a rare and heterogeneous sarcoma with diverse clinical presentations.Local wide resection is the cornerstone of angiosarcoma treatment,and adjuvant therapy may improve its prognosis.