CAJ | 학술논문

目的：探讨长托宁联合昂丹司琼在预防全麻下妇科腹腔镜手术术后恶心呕吐（PONV）的临床效果。方法选取90例ASAⅠ～Ⅱ级,择期进行妇科腹腔镜手术的患者，随机分成A、B、C三组。A组为对照组、B组为昂丹司琼组、C组为长托宁联合昂丹司琼组,观察术后24h内患者恶心呕吐的发生几率及程度。结果 C组及B组术后24h内PONV的发生率和程度较A组明显减轻,P<0.05，差别有统计学意义；C组较B组术后24h内PONV的发生率和程度更低,P<0.05，差别有统计学意义。结论长托宁联合昂丹司琼预防PONV有协同作用,可降低PONV的发生率及严重程度。
목적：탐토장탁저연합앙단사경재예방전마하부과복강경수술술후악심구토（PONV）적림상효과。방법선취90례ASAⅠ～Ⅱ급,택기진행부과복강경수술적환자，수궤분성A、B、C삼조。A조위대조조、B조위앙단사경조、C조위장탁저연합앙단사경조,관찰술후24h내환자악심구토적발생궤솔급정도。결과 C조급B조술후24h내PONV적발생솔화정도교A조명현감경,P<0.05，차별유통계학의의；C조교B조술후24h내PONV적발생솔화정도경저,P<0.05，차별유통계학의의。결론장탁저연합앙단사경예방PONV유협동작용,가강저PONV적발생솔급엄중정도。
Subject:This study aimed to investigate the clinical effect of the combination of penehyclidine hydrochloride and ondansetron on prevention of postoperative nausea and vomiting (PONV)after gynecological laparoscopic surgery under general anesthesia.Methods:90 ASA I-I patients undergoing elective laparoscopic operations were divided into three groups, and normal saline(group A),ondansetron(group B) or penehyclidine hydrochloride combined with ondansetron (group C) were given randomly.The incidence and severity of PONV were recorded 24 hours after surgery.Results:The incidences and severity of PONV in group A were higher than group A and group B significantly (P < 0.05). And there were significant differences in the incidence and severity of PONV in group C and group B (P<0.05).Conclusion: The synergistic effect of penehyclidine hydrochloride combined with ondansetron was effective in reducing the incidence and severity of PONV.