中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
2期
279-281
,共3页
孕妇%新生儿%维生素D%肌注%临床干预
孕婦%新生兒%維生素D%肌註%臨床榦預
잉부%신생인%유생소D%기주%림상간예
pregnant women%neonates%vitamin D%intramuscular injection%clinical intervention
目的：通过对维生素D缺乏孕妇进行单次、单剂量肌注补充维生素D，对其有效性和安全性进行研究。方法检测孕妇维生素D水平，将60例维生素D缺乏的孕妇随机分为干预组和对照组各30例。对干预组孕妇在其36～38孕周时，进行一次性肌注维生素D37．5mg（30万单位），分析比较干预组与对照组的孕妇及其新生儿血清维生素D水平。结果产时（干预后）干预组孕妇的血清25-（OH）D高于对照组，差异有统计学意义（t＝6．13，P＜0．05）；干预组新生儿的血清25-（OH）D也高于对照组，差异有统计学意义（t＝4．99，P＜0．05）。干预组孕母和新生儿脐血25-（OH）D水平呈正相关（r＝0．53，P＜0．05）；对照组孕母和新生儿脐血25-（OH）D水平也呈正相关（r＝0．63，P＜0．05）。结论孕妇、新生儿体内维生素D水平普遍比较低，单剂量肌注补充维生素D3的干预措施对改善孕妇及其新生儿维生素D的状况有效并且安全。
目的：通過對維生素D缺乏孕婦進行單次、單劑量肌註補充維生素D，對其有效性和安全性進行研究。方法檢測孕婦維生素D水平，將60例維生素D缺乏的孕婦隨機分為榦預組和對照組各30例。對榦預組孕婦在其36～38孕週時，進行一次性肌註維生素D37．5mg（30萬單位），分析比較榦預組與對照組的孕婦及其新生兒血清維生素D水平。結果產時（榦預後）榦預組孕婦的血清25-（OH）D高于對照組，差異有統計學意義（t＝6．13，P＜0．05）；榦預組新生兒的血清25-（OH）D也高于對照組，差異有統計學意義（t＝4．99，P＜0．05）。榦預組孕母和新生兒臍血25-（OH）D水平呈正相關（r＝0．53，P＜0．05）；對照組孕母和新生兒臍血25-（OH）D水平也呈正相關（r＝0．63，P＜0．05）。結論孕婦、新生兒體內維生素D水平普遍比較低，單劑量肌註補充維生素D3的榦預措施對改善孕婦及其新生兒維生素D的狀況有效併且安全。
목적：통과대유생소D결핍잉부진행단차、단제량기주보충유생소D，대기유효성화안전성진행연구。방법검측잉부유생소D수평，장60례유생소D결핍적잉부수궤분위간예조화대조조각30례。대간예조잉부재기36～38잉주시，진행일차성기주유생소D37．5mg（30만단위），분석비교간예조여대조조적잉부급기신생인혈청유생소D수평。결과산시（간예후）간예조잉부적혈청25-（OH）D고우대조조，차이유통계학의의（t＝6．13，P＜0．05）；간예조신생인적혈청25-（OH）D야고우대조조，차이유통계학의의（t＝4．99，P＜0．05）。간예조잉모화신생인제혈25-（OH）D수평정정상관（r＝0．53，P＜0．05）；대조조잉모화신생인제혈25-（OH）D수평야정정상관（r＝0．63，P＜0．05）。결론잉부、신생인체내유생소D수평보편비교저，단제량기주보충유생소D3적간예조시대개선잉부급기신생인유생소D적상황유효병차안전。
objective To determine the effectiveness and safety of a single dose of intramuscular injection of vitamin D in pregnant women . Methods The serum vitamin D level of pregnant women was measured .Sixty pregnant women of vitamin D deficiency were randomly divided into two even groups:intervention group and control group .The intervention group received disposable intramuscular injection of vitamin D3 7.5mg (300,000 units) during their 36-38 weeks of gestation , and the serum vitamin D level of pregnant women and neonates were compared between intervention group and control group .Results The 25-( OH) D serum levels of pregnant women and neonates in the intervention group were significantly higher than those in the control group (t value was 6.13 and 4.99, respectively, both P<0.05).The 25-( OH) D level in pregnant women was positively correlated with that in neonates cord blood in intervention group and control group ( r value was 0.53 and 0.63, respectively, both P<0.05).Conclusion The level of vitamin D in pregnant women and neonates is generally low.A single dose of intramuscular injection of vitamin D 3 is effective and safe in improving vitamin D status both in pregnant women and neonates .
