中国急救医学
中國急救醫學
중국급구의학
CHINESE JOURNAL OF CRITICAL CARE MEDICINE
2014年
10期
877-880
,共4页
王晓丹(综述)%张玉想(审校)
王曉丹(綜述)%張玉想(審校)
왕효단(종술)%장옥상(심교)
信号转导子和转录激活子3(STAT3)%脓毒症%白细胞介素-6(IL-6)%Th17
信號轉導子和轉錄激活子3(STAT3)%膿毒癥%白細胞介素-6(IL-6)%Th17
신호전도자화전록격활자3(STAT3)%농독증%백세포개소-6(IL-6)%Th17
STAT3%Sepsis%IL-6%Th17
STAT3信号通路在细胞的增殖、分化、凋亡和血管生成等方面起着重要作用，进而在肿瘤的发生发展机制领域被广泛研究。然而，近年来发现，STAT3还具有调节炎症反应的作用，使得对炎症性疾病---脓毒症发病机制的研究取得了极大的进步。现对近年来STAT3在脓毒症发病机制方面的研究进展进行综述，以帮助人类找到防治脓毒症的新的思路和策略。
STAT3信號通路在細胞的增殖、分化、凋亡和血管生成等方麵起著重要作用，進而在腫瘤的髮生髮展機製領域被廣汎研究。然而，近年來髮現，STAT3還具有調節炎癥反應的作用，使得對炎癥性疾病---膿毒癥髮病機製的研究取得瞭極大的進步。現對近年來STAT3在膿毒癥髮病機製方麵的研究進展進行綜述，以幫助人類找到防治膿毒癥的新的思路和策略。
STAT3신호통로재세포적증식、분화、조망화혈관생성등방면기착중요작용，진이재종류적발생발전궤제영역피엄범연구。연이，근년래발현，STAT3환구유조절염증반응적작용，사득대염증성질병---농독증발병궤제적연구취득료겁대적진보。현대근년래STAT3재농독증발병궤제방면적연구진전진행종술，이방조인류조도방치농독증적신적사로화책략。
STAT3 signaling pathway plays an important role in multiple cellular functions such as cell proliferation , differentiation , apoptosis and angiogenesis , therefore its mechanism in developing tumor has been widely studied .In recent years, however, we found that STAT3 plays a role in the regulation of inflammatory reaction , which greatly improved the investigations of the pathogenesis of sepsis.In this review, the progresses of STAT3 in the pathogenesis of sepsis in recent year are reviewed , in order to help human to find new ideas and strategies for the prevention and control of sepsis .
