CAJ | 학술논문

目的：探讨早期肠内营养联合肠内免疫微生态营养（EIN）对肝癌肝切除患者术后早期肝功能及肠道功能的影响。方法将80例肝癌肝切除患者随机进入EIN组和肠外营养（PN）组。比较两组患者术后1、3、7 d的血白细胞计数、谷丙转氨酶（ALT）、总胆红素（TBIL）、白蛋白补充量、血浆内毒素及术后7 d内肠道排气时间及大便球杆比异常率。结果EIN组和PN组患者术后血白细胞计数变化差异无统计学意义，而术后第7天，EIN组患者ALT、TBIL恢复优于PN组，血浆白蛋白补充量少于PN组；肠道恢复时间早于PN组，同时大便球杆比异常率较PN组低（P ＜0.05）。结论肝癌肝切除术患者早期实施肠内营养联合肠内免疫微生态支持治疗可以补充肠道正常菌群，减少细菌易位，减少内毒素血症及炎症因子的发生，有利于肝切除患者术后肝功能的恢复。
목적：탐토조기장내영양연합장내면역미생태영양（EIN）대간암간절제환자술후조기간공능급장도공능적영향。방법장80례간암간절제환자수궤진입EIN조화장외영양（PN）조。비교량조환자술후1、3、7 d적혈백세포계수、곡병전안매（ALT）、총담홍소（TBIL）、백단백보충량、혈장내독소급술후7 d내장도배기시간급대편구간비이상솔。결과EIN조화PN조환자술후혈백세포계수변화차이무통계학의의，이술후제7천，EIN조환자ALT、TBIL회복우우PN조，혈장백단백보충량소우PN조；장도회복시간조우PN조，동시대편구간비이상솔교PN조저（P ＜0.05）。결론간암간절제술환자조기실시장내영양연합장내면역미생태지지치료가이보충장도정상균군，감소세균역위，감소내독소혈증급염증인자적발생，유리우간절제환자술후간공능적회복。
Objective To approach the effects of combining early enteral nutritioning with immunonutrition(EIN) on the liver function and gut function in the hepatoma patients receiving hepatectomy. Methods Eighty patients who received hepatectomy were randomly assigned to EIN group and parenteral nutrition (PN) group right after operation. At the 1st, 3rd and 7th day after operation, the peripheral white blood cells, ALT, TBIL, the supplement of albumin, plasma endotoxi, postoperation exhaust time and the abnormal rate of fecal microflora were measured. Results There was no significant difference in peripheral white blood cells between the two groups. The patients in EIN group had a better recovery of ALT and TBIL, the plasma endotoxi and the fecal microflora abnormal rate was lower than those in PN group. Conclusion Therapy of combining early enteral nutrition with immunonutrition has favorable benefit on liver function and gut function than PN therapy, and therefore can quicken the recovery in the hepatoma patients receiving hepatectomy.