CAJ | 학술논문

目的：研究体检人群血糖（GLU）与血浆致动脉硬化指数（AIP）、超敏 C 反应蛋白（HCRP）、血脂系列等指标的相关性，为临床评估高血糖及并发心脑血管疾病风险提供实验检测依据。方法使用奥林巴斯 AU5400全自动生化分析仪测定9057名体检人员 GLU、HCRP 及血脂系列等指标，计算 AIP 值，用 t 检验或方差分析不同性别、年龄、血糖组间这些测定指标的差异；采用 Pearson 相关分析各指标之间的相关性，再用多因素 Logistic回归分析高血糖的相关危险因素。结果男女高血糖组 AIP、HCRP 水平均高于非高血糖组人群（P ＜0.01）。GLU 与 AIP、载脂蛋白 B （apoB）、HCRP、低密度脂蛋白-胆固醇（LDL -C）、总胆固醇（TC）、甘油三酯（TG）、尿酸（URIC）、apoB/apoA1呈较低程度的正相关，其中与 AIP 相关性最高（r ＝0.163，P ＜0.01）；GLU与载脂蛋白 A1（apoA1）、高密度脂蛋白胆固醇（HDL -C）呈负相关。多因素 Logistic 回归分析显示：男性、年龄、HCRP、AIP 和高血糖存在关联。结论高血糖人群的 AIP、HCRP 平均水平高于非高血糖人群。建议2型糖尿病患者应重视血糖、AIP 和 HCRP 等指标的监控，以为防止并发心脑血管疾病。
목적：연구체검인군혈당（GLU）여혈장치동맥경화지수（AIP）、초민 C 반응단백（HCRP）、혈지계렬등지표적상관성，위림상평고고혈당급병발심뇌혈관질병풍험제공실험검측의거。방법사용오림파사 AU5400전자동생화분석의측정9057명체검인원 GLU、HCRP 급혈지계렬등지표，계산 AIP 치，용 t 검험혹방차분석불동성별、년령、혈당조간저사측정지표적차이；채용 Pearson 상관분석각지표지간적상관성，재용다인소 Logistic회귀분석고혈당적상관위험인소。결과남녀고혈당조 AIP、HCRP 수평균고우비고혈당조인군（P ＜0.01）。GLU 여 AIP、재지단백 B （apoB）、HCRP、저밀도지단백-담고순（LDL -C）、총담고순（TC）、감유삼지（TG）、뇨산（URIC）、apoB/apoA1정교저정도적정상관，기중여 AIP 상관성최고（r ＝0.163，P ＜0.01）；GLU여재지단백 A1（apoA1）、고밀도지단백담고순（HDL -C）정부상관。다인소 Logistic 회귀분석현시：남성、년령、HCRP、AIP 화고혈당존재관련。결론고혈당인군적 AIP、HCRP 평균수평고우비고혈당인군。건의2형당뇨병환자응중시혈당、AIP 화 HCRP 등지표적감공，이위방지병발심뇌혈관질병。
Objective The aim was to find the correlations between blood glucose (GLU)and atherogenic index of plasma (AIP),high sensitive C reactive protein (HCRP),plasma lipid profiles among physical examination population.Methods The parameters including GLU,HCRP,and plasma lipid profiles were examined by using Olympus AU5400 automatic biochemical analyzer from 9 057 blood samples,and then AIP value was calculated.The t test,Pearson correlation and multivariate logistic regression were used.Results The levels of AIP and HCRP were significantly higher in high glucose group both in males and females (P <0.01).Positive lower correlations were found between GLU and AIP,apolipoprotein B (apoB),HCRP,low density lipoprotein cholesterol (LDL -C),total cholesterol (TC),triglyceride (TG),uric acid (URIC)and apoB/aopA1,while the correlation with AIP was highest (r =0.163,P <0.01 ).There were negative correlations between GLU and apoA1,high density lipoprotein cholesterol (HDL -C).Results of multivariate logistic regression analysis showed that male gender,age,HCRP and AIP were relative factors associated with hyperglycemia. Conclusion There are some differences in the levels of AIP and HCRP between the high glucose people and general people.