浙江临床医学
浙江臨床醫學
절강림상의학
ZHEJIANG CLINICAL MEDICAL JOURNAL
2014年
4期
516-518
,共3页
张吉水%姬汉书%高新%郭忠建%王文龙%刘雅刚
張吉水%姬漢書%高新%郭忠建%王文龍%劉雅剛
장길수%희한서%고신%곽충건%왕문룡%류아강
肿瘤特异性生长因子%糖类肿瘤相关抗原%梗阻性黄疸
腫瘤特異性生長因子%糖類腫瘤相關抗原%梗阻性黃疸
종류특이성생장인자%당류종류상관항원%경조성황달
Tumor specific growth factor(TSGF)%Carbohydrate tumor-associated antigen(CA 19-9)%Obstructive jaundice
目的:探讨肿瘤特异性生长因子(TSGF)和糖类肿瘤相关抗原(CA 19-9)在大鼠梗阻性黄疸模型肝组织中的表达及意义。方法采用快速检测试剂盒检测模型组和对照组(各30只大鼠)肝脏组织中的TSGF和CA 19-9表达水平,用t检验、关联性分析等比较组间差异,分析其生物学意义。结果模型组大鼠各时间点TB、ALT、AST等指标均明显高于对照组(P<0.05),ALB明显低于对照组(P<0.05);模型组术TSGF、CA 19-9水平均明显高于对照组(P<0.05),且随手术时间延长而升高(R=0.970,P=0.006;R=0.987,P=0.006);TSGF及CA 19-9与TB呈较强的正相关关系(R=0.9196,R=0.7808), TSGF及CA 19-9与ALB呈较强的负相关关系(R=-0.8494,R=-0.7024,P<0.05)。结论梗阻性黄疸大鼠模型的肝脏功能损伤越严重,TSGF、CA 19-9水平越高,提示肿瘤越有可能存在,对于梗阻性黄疸患者应及早进行治疗,以避免病情恶化。
目的:探討腫瘤特異性生長因子(TSGF)和糖類腫瘤相關抗原(CA 19-9)在大鼠梗阻性黃疸模型肝組織中的錶達及意義。方法採用快速檢測試劑盒檢測模型組和對照組(各30隻大鼠)肝髒組織中的TSGF和CA 19-9錶達水平,用t檢驗、關聯性分析等比較組間差異,分析其生物學意義。結果模型組大鼠各時間點TB、ALT、AST等指標均明顯高于對照組(P<0.05),ALB明顯低于對照組(P<0.05);模型組術TSGF、CA 19-9水平均明顯高于對照組(P<0.05),且隨手術時間延長而升高(R=0.970,P=0.006;R=0.987,P=0.006);TSGF及CA 19-9與TB呈較彊的正相關關繫(R=0.9196,R=0.7808), TSGF及CA 19-9與ALB呈較彊的負相關關繫(R=-0.8494,R=-0.7024,P<0.05)。結論梗阻性黃疸大鼠模型的肝髒功能損傷越嚴重,TSGF、CA 19-9水平越高,提示腫瘤越有可能存在,對于梗阻性黃疸患者應及早進行治療,以避免病情噁化。
목적:탐토종류특이성생장인자(TSGF)화당류종류상관항원(CA 19-9)재대서경조성황달모형간조직중적표체급의의。방법채용쾌속검측시제합검측모형조화대조조(각30지대서)간장조직중적TSGF화CA 19-9표체수평,용t검험、관련성분석등비교조간차이,분석기생물학의의。결과모형조대서각시간점TB、ALT、AST등지표균명현고우대조조(P<0.05),ALB명현저우대조조(P<0.05);모형조술TSGF、CA 19-9수평균명현고우대조조(P<0.05),차수수술시간연장이승고(R=0.970,P=0.006;R=0.987,P=0.006);TSGF급CA 19-9여TB정교강적정상관관계(R=0.9196,R=0.7808), TSGF급CA 19-9여ALB정교강적부상관관계(R=-0.8494,R=-0.7024,P<0.05)。결론경조성황달대서모형적간장공능손상월엄중,TSGF、CA 19-9수평월고,제시종류월유가능존재,대우경조성황달환자응급조진행치료,이피면병정악화。
Objective To investigate the expressions of TSGF and CA 19-9 and their significance in the liver of rat model of obstructive jaundice. Methods Rapid detection kit was to used detect the expression levels of TSGF and CA 19-9 of the model group and the control(30 rats each). T-test and correlation analysis were explored the differences and significance between groups. Results TB,ALT,AST of the rats in the model were significantly higher(P<0.05),ALB was significantly lower than that of the control group(P<0.05);TSGF,CA 19-9 levels of the model group were significantly higher(P<0.05)and increased with operative time prolonged(R=0.970,P=0.006;R=0.987,P=0.006);TSGF and CA 19-9 had a strong positive correlation with TB (R=0.9196,R=0.7808)and showed a strong negative correlation with ALB(R=-0.8494,R=-0.7024)(P<0.05). Conclusion The liver function of rat model of obstructive jaundice had serious injury. TSGF,CA 19-9 level is higher,suggesting that the tumor is more likely to exist;also suggesting clinically for patients with obstructive jaundice be treated as soon as possible to avoid deterioration.