CAJ | 학술논문

肿瘤生长和转移的基础是新血管的生成，而新血管的生成主要取决于血管生长因子及其抑制因子的调控，其中研究最多、最重要的是血管内皮生长因子(VEGF)及其受体。VEGF是目前发现最重要的促进肿瘤血管形成的因子，可增加血管通透性、促进血管内皮细胞增殖，参与肿瘤生长和淋巴管转移。人体多种实体瘤均有VEGF及其受体的过高表达，其在肿瘤组织和血清中的显著表达促进肿瘤血管的形成，并与预后密切相关。
종류생장화전이적기출시신혈관적생성，이신혈관적생성주요취결우혈관생장인자급기억제인자적조공，기중연구최다、최중요적시혈관내피생장인자(VEGF)급기수체。VEGF시목전발현최중요적촉진종류혈관형성적인자，가증가혈관통투성、촉진혈관내피세포증식，삼여종류생장화림파관전이。인체다충실체류균유VEGF급기수체적과고표체，기재종류조직화혈청중적현저표체촉진종류혈관적형성，병여예후밀절상관。
Neovascularization is the basis of tumor growth and metastasis. Angiogenesis depends mainly on the regulation of vascular endothelial growth factor and angiogenesis inhibiting factor. The vascular endothelial growth factor and its receptor are the most important and are studied most. The expression of them increased significantly in gastric cancer tissue and serum.. They promote angiogenesis of tumor. They are closely related to the prognosis of patient. The vascular endothelial growth factor and its receptor in the gastric cancer are reviewed in this article.