CAJ | 학술논문

目的：探讨运用320排CT双入口灌注成像技术，评估结核病灶灌注参数值对肺结核化疗近期效果的预测作用。方法：将30例肺结核按形态学分为结核球、空洞型病灶和浸润型病灶三组。化疗前7 d内CT检查与化疗后30 d的CT平扫结果进行比较，根据标准评定疗效分成缓解组与未缓解组。化疗前7 d内及化疗后14 d行2次CT灌注扫描，比较化疗前、化疗后早期CT灌注参数的变化与化疗疗效的关系。结果：30例患者中缓解组20例，非缓解组10例；化疗前与化疗后早期病灶大小进行比较，均未见明显变化。化疗前及化疗后早期CT各灌注参数在两组中均有变化。缓解组结核的治疗前PF、BF值高于未缓解组，其差异有统计学意义(t=6.23，t=7.61；P＜0.001)，缓解组中结核病灶灌注值治疗前后有显著性差异，灌注值有所下降，未缓解组中治疗前后结核病灶灌注值升高，BF值治疗前14.06±4.09，治疗后升至36.68±4.41，其差异显著。PF值虽轻度升高，但无显著性差异。结论：320排双入口灌注技术对肺结核化疗后早期疗效的评估有一定的价值。肺结核治疗后的灌注值变化与近期疗效相关，BF值升高提示结核病灶进展，预后较差。
목적：탐토운용320배CT쌍입구관주성상기술，평고결핵병조관주삼수치대폐결핵화료근기효과적예측작용。방법：장30례폐결핵안형태학분위결핵구、공동형병조화침윤형병조삼조。화료전7 d내CT검사여화료후30 d적CT평소결과진행비교，근거표준평정료효분성완해조여미완해조。화료전7 d내급화료후14 d행2차CT관주소묘，비교화료전、화료후조기CT관주삼수적변화여화료료효적관계。결과：30례환자중완해조20례，비완해조10례；화료전여화료후조기병조대소진행비교，균미견명현변화。화료전급화료후조기CT각관주삼수재량조중균유변화。완해조결핵적치료전PF、BF치고우미완해조，기차이유통계학의의(t=6.23，t=7.61；P＜0.001)，완해조중결핵병조관주치치료전후유현저성차이，관주치유소하강，미완해조중치료전후결핵병조관주치승고，BF치치료전14.06±4.09，치료후승지36.68±4.41，기차이현저。PF치수경도승고，단무현저성차이。결론：320배쌍입구관주기술대폐결핵화료후조기료효적평고유일정적개치。폐결핵치료후적관주치변화여근기료효상관，BF치승고제시결핵병조진전，예후교차。
Objective:To explore the use of double- entry 320 -slice CT perfusion imaging techniques to assess the effect of tuberculosis perfusion parameters to predict short-term effect of tuberculosis chemotherapy.Methods: Divided 30 cases of tuberculosis into three groups. Compare the two results of one week pre chemotherapy and post chemotherapy with 30d CT scan, divided into clinical remission group and non-remission group according to the standard of evaluating the effect. One week before chemotherapy and after chemotherapy 14d twice CT perfusion scan, comparing with pre and post chemotherapy relationship changes of early CT perfusion parameters.Results: In 30 patients there were 20 cases of remission and 10 cases of non-remission. In 30 patients, compared early lesion size pre chemotherapy and post chemotherapy, there were no significant changes: chemotherapy before and after chemotherapy early CT perfusion parameters in both groups were changed. PF and BF of TB treatment before remission group was higher than the non-remission group before treatment, BF14.06 ± 4.09, the difference was statistically significant (t=6.23,7.61,P=0.001), remission group tuberculosis perfusion values before and after treatment there was a significant difference in perfusion values decline, and no relief after perfusion values tuberculosis treatment group increased BF values before treatment after treatment rose to 36.68 ± 4.41, the difference was statistically significant. PF value is slightly elevated. It is no significant difference.Conclusion: It was valuable that 320 double row of perfusion technique for assessing early entrance efficacy of tuberculosis chemotherapy after a certain. Changes in pulmonary perfusion after treatment with short-term effect related, BF increased indicated that the tuberculose focus has progressed and a poor prognosis.