实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2014年
4期
571-573
,共3页
刘磊%王凤梅%阚志超%李岩%肖时湘%刘华%李莹
劉磊%王鳳梅%闞誌超%李巖%肖時湘%劉華%李瑩
류뢰%왕봉매%감지초%리암%초시상%류화%리형
评分系统%乙型肝炎%慢加急性肝衰竭%预后%受试者工作特征曲线%曲线下面积
評分繫統%乙型肝炎%慢加急性肝衰竭%預後%受試者工作特徵麯線%麯線下麵積
평분계통%을형간염%만가급성간쇠갈%예후%수시자공작특정곡선%곡선하면적
Scoring system%Acute on chronic liver failure%Prognosis%receiver operating characteristic curve (ROC curve)%area under the curve (AUC)
目的:通过对几种不同评分系统比较,找出更适合乙肝相关慢加急性肝衰竭患者短期预后评估的方法。方法:将142例乙肝相关慢加急性肝衰竭患者根据其3个月后的存活及死亡情况,分为存活组(n=72)及病死组(n=70),分别计算 CTP、MELD、ANN、SOFA 、SMSVH 、LRM 等评分,行 ROC 曲线分析,计算曲线下面积,并进行比较。结果:ROC曲线下面积从大到小分别为ANN、SOFA 、LRM、MELD、CTP、SMSVH ,相应数值分别为0.92、0.89、0.89、0.87、0.78和0.69。ANN、SOFA 、LRM、MELD的AUC之间比较差异无统计学意义(P >0.05),ANN、SOFA 、LRM、MELD 的 AUC 值> CTP、SMSVH,差异有统计学意义(P 均<0.05), CTP 的 AUC 值>SMSVH,差异有统计学意义(P<0.05)。结论:ANN、SOFA 、LRM、MELD 较好;CTP 稍差;SMSVH最差,不适用于乙肝相关慢加急性肝衰竭患者短期预后判断。 ANN可能为最佳评分系统,但仍需大样本、多中心、动态的临床观察来证实。
目的:通過對幾種不同評分繫統比較,找齣更適閤乙肝相關慢加急性肝衰竭患者短期預後評估的方法。方法:將142例乙肝相關慢加急性肝衰竭患者根據其3箇月後的存活及死亡情況,分為存活組(n=72)及病死組(n=70),分彆計算 CTP、MELD、ANN、SOFA 、SMSVH 、LRM 等評分,行 ROC 麯線分析,計算麯線下麵積,併進行比較。結果:ROC麯線下麵積從大到小分彆為ANN、SOFA 、LRM、MELD、CTP、SMSVH ,相應數值分彆為0.92、0.89、0.89、0.87、0.78和0.69。ANN、SOFA 、LRM、MELD的AUC之間比較差異無統計學意義(P >0.05),ANN、SOFA 、LRM、MELD 的 AUC 值> CTP、SMSVH,差異有統計學意義(P 均<0.05), CTP 的 AUC 值>SMSVH,差異有統計學意義(P<0.05)。結論:ANN、SOFA 、LRM、MELD 較好;CTP 稍差;SMSVH最差,不適用于乙肝相關慢加急性肝衰竭患者短期預後判斷。 ANN可能為最佳評分繫統,但仍需大樣本、多中心、動態的臨床觀察來證實。
목적:통과대궤충불동평분계통비교,조출경괄합을간상관만가급성간쇠갈환자단기예후평고적방법。방법:장142례을간상관만가급성간쇠갈환자근거기3개월후적존활급사망정황,분위존활조(n=72)급병사조(n=70),분별계산 CTP、MELD、ANN、SOFA 、SMSVH 、LRM 등평분,행 ROC 곡선분석,계산곡선하면적,병진행비교。결과:ROC곡선하면적종대도소분별위ANN、SOFA 、LRM、MELD、CTP、SMSVH ,상응수치분별위0.92、0.89、0.89、0.87、0.78화0.69。ANN、SOFA 、LRM、MELD적AUC지간비교차이무통계학의의(P >0.05),ANN、SOFA 、LRM、MELD 적 AUC 치> CTP、SMSVH,차이유통계학의의(P 균<0.05), CTP 적 AUC 치>SMSVH,차이유통계학의의(P<0.05)。결론:ANN、SOFA 、LRM、MELD 교호;CTP 초차;SMSVH최차,불괄용우을간상관만가급성간쇠갈환자단기예후판단。 ANN가능위최가평분계통,단잉수대양본、다중심、동태적림상관찰래증실。
Objective To assessment short-term prognosis in patients with acute on chronic liver failure , several scoring systems were compared. Methods Two hundred and sixteen patients with acute on chronic liver failure were divided into survival group and death group according to the results of 90 days after admission.CTP , MELD,APACHEⅡ, SOFA and SMSVH score were calculated.After ROC curves were performed ,the areas under the curves of these scoring systems were compared. Results The areas under the ROC curves of MELD, APACHEⅡ, SOFA, CTP and SMSVH were 0.88, 0.76, 0.89,0.79and 0.69,respectively. The areas under the curves of SOFA and MELD were larger than the APACHEⅡ, CTP and SMSVH (P<0.05). There was no difference between the SOFA and MELD (P>0.05). The area under the curve of CTP was larger than the APACHEⅡ, but there was no statistically significant difference (P > 0.05). The area under the curve of SMSVH were less than 0.7. Conclusions The SOFA, MELD,CTP and APACHEⅡcan predict the short-term prognosis of acute on chronic liver failure. The SOFA and MELD are the best scoring systems.CTP,APACHEⅡ are better than SMSVH. SMSVH fail to predict the prognosis of acute on chronic liver failure.