临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2014年
20期
31-32
,共2页
降钙素原%白介素-6%C-反应蛋白%社区获得性肺炎
降鈣素原%白介素-6%C-反應蛋白%社區穫得性肺炎
강개소원%백개소-6%C-반응단백%사구획득성폐염
PCT%IL-6%C-reactive protein%Community acquired pneumonia
目的：探讨成人社区获得性肺炎（CAP）患者 PCT、IL-6、CRP 检测的临床意义。方法选择2012年12月-2013年7月住院的成人 CAP 患者105例作为观察组，同期于体检中心随机抽取33例健康体检者作为对照组，观察组于入院后运用抗生素前、治疗后第3、7天抽取静脉血，对照组于体检当天抽取静脉血，2组均采用电化学发光法测定血清 PCT、IL-6浓度，散射比浊法测定血清 CRP 浓度，比较2组间及观察组治疗前后 PCT、IL-6、CRP 浓度。结果 CAP 观察组血清 PCT、IL-6、CRP、wBC 计数、中性粒细胞百分比测定值均明显高于健康对照组，差异有统计学意义（P ﹤0.05）；CAP 观察组血清 PCT、IL-6、CRP 浓度治疗前均明显高于治疗后第3、7天，差异有统计学意义（ P ﹤0.05）。结论血清 PCT、IL-6和 CRP 测定对 CAP 有一定的诊断价值，且可以作为疗效观察的重要指标。
目的：探討成人社區穫得性肺炎（CAP）患者 PCT、IL-6、CRP 檢測的臨床意義。方法選擇2012年12月-2013年7月住院的成人 CAP 患者105例作為觀察組，同期于體檢中心隨機抽取33例健康體檢者作為對照組，觀察組于入院後運用抗生素前、治療後第3、7天抽取靜脈血，對照組于體檢噹天抽取靜脈血，2組均採用電化學髮光法測定血清 PCT、IL-6濃度，散射比濁法測定血清 CRP 濃度，比較2組間及觀察組治療前後 PCT、IL-6、CRP 濃度。結果 CAP 觀察組血清 PCT、IL-6、CRP、wBC 計數、中性粒細胞百分比測定值均明顯高于健康對照組，差異有統計學意義（P ﹤0.05）；CAP 觀察組血清 PCT、IL-6、CRP 濃度治療前均明顯高于治療後第3、7天，差異有統計學意義（ P ﹤0.05）。結論血清 PCT、IL-6和 CRP 測定對 CAP 有一定的診斷價值，且可以作為療效觀察的重要指標。
목적：탐토성인사구획득성폐염（CAP）환자 PCT、IL-6、CRP 검측적림상의의。방법선택2012년12월-2013년7월주원적성인 CAP 환자105례작위관찰조，동기우체검중심수궤추취33례건강체검자작위대조조，관찰조우입원후운용항생소전、치료후제3、7천추취정맥혈，대조조우체검당천추취정맥혈，2조균채용전화학발광법측정혈청 PCT、IL-6농도，산사비탁법측정혈청 CRP 농도，비교2조간급관찰조치료전후 PCT、IL-6、CRP 농도。결과 CAP 관찰조혈청 PCT、IL-6、CRP、wBC 계수、중성립세포백분비측정치균명현고우건강대조조，차이유통계학의의（P ﹤0.05）；CAP 관찰조혈청 PCT、IL-6、CRP 농도치료전균명현고우치료후제3、7천，차이유통계학의의（ P ﹤0.05）。결론혈청 PCT、IL-6화 CRP 측정대 CAP 유일정적진단개치，차가이작위료효관찰적중요지표。
Objective To investigate the clinical significance of serum PCT,IL-6 and CRP in adult patients with com-munity acquired pneumonia(CAP). Methods 105 patients with CAP who hospitalized during the period of December 2012 to July 2013 were admitted as CAP group. meanwhile,33 normal healthy individuals were taken as control group. Blood samples of CAP group were extracted before using antibiotics and after treatment for 3,7 days,which of the control group were extracted on the day of physical examination. The PCT and IL-6 level of 2 groups were determined by electrochemical luminescence method,and the CRP level was determined by immunity-turbidity method. Results The Serum PCT,IL-6 and CRP levels of the CAP group were significantly higher than the normal control group,the differences were statistically significant(P ﹤ 0. 05). The serum PCT,IL-6 and CRP levels before treatment were significantly higher than the 3 and 7 days after treatment in CAP group,the differences were statistically significant(P ﹤ 0. 05). Conclusion The serum PCT,IL-6 and CRP have diagnostic value for the CAP,and may could be as the objective marker for clinical effect observation.
