CAJ | 학술논문

目的：探讨不同收缩压（SBP）水平对臂踝脉搏波传导速度（baPWV）的影响。方法在101510名参加2006-2007年开滦集团职工健康体检者中随机分层抽取5852人作为研究对象进行横断面研究，采用统一问卷调查、血液生化及baPWV检查，其中符合入选标准（年龄≥40岁、既往无缺血性脑卒中、短暂性脑缺血发作、心肌梗死者）5440人，将资料完整的5222人纳入统计分析。依据2010-2011年度体检时SBP值将研究对象分为理想SBP组（SBP＜120 mmHg）、正常高值Ⅰ期组（120 mmHg≤SBP＜130 mmHg）、正常高值Ⅱ期组（130 mmHg≤SBP＜140 mmHg）、高血压组（SBP≥140 mmHg或＜140 mmHg但正在服用降压药物者）。利用多因素logistic回归分析不同SBP水平对baPWV的影响。结果（1）5222（男性3132，女性2090）名研究对象平均年龄55.1岁，平均baPWV（1587.57±400.71）cm/s，baPWV≥1400 cm/s的检出率为62%；（2）4组人群平均baPWV分别为1322.19、1456.27、1544.78、1827.77 cm/s，baPWV≥1400 cm/s的检出率分别为26.4%、49.3%、64.2%、88.3%；（3）多因素线性回归分析显示SBP的标准化β值为0.40，仅次于年龄的0.48；（4）影响baPWV的多因素logistic回归分析显示，校正年龄、性别等因素后，与理想SBP组比较，正常高值Ⅰ期、正常高值Ⅱ期和高血压组均为baPWV≥1400 cm/s的危险因素，OR值分别为2.70（95%CI：2.20～3.32）、4.56（95%CI：3.67～5.67）和13.51（95%CI：10.87～16.78）。结论SBP升高是baPWV增加的独立危险因素。
목적：탐토불동수축압（SBP）수평대비과맥박파전도속도（baPWV）적영향。방법재101510명삼가2006-2007년개란집단직공건강체검자중수궤분층추취5852인작위연구대상진행횡단면연구，채용통일문권조사、혈액생화급baPWV검사，기중부합입선표준（년령≥40세、기왕무결혈성뇌졸중、단잠성뇌결혈발작、심기경사자）5440인，장자료완정적5222인납입통계분석。의거2010-2011년도체검시SBP치장연구대상분위이상SBP조（SBP＜120 mmHg）、정상고치Ⅰ기조（120 mmHg≤SBP＜130 mmHg）、정상고치Ⅱ기조（130 mmHg≤SBP＜140 mmHg）、고혈압조（SBP≥140 mmHg혹＜140 mmHg단정재복용강압약물자）。이용다인소logistic회귀분석불동SBP수평대baPWV적영향。결과（1）5222（남성3132，녀성2090）명연구대상평균년령55.1세，평균baPWV（1587.57±400.71）cm/s，baPWV≥1400 cm/s적검출솔위62%；（2）4조인군평균baPWV분별위1322.19、1456.27、1544.78、1827.77 cm/s，baPWV≥1400 cm/s적검출솔분별위26.4%、49.3%、64.2%、88.3%；（3）다인소선성회귀분석현시SBP적표준화β치위0.40，부차우년령적0.48；（4）영향baPWV적다인소logistic회귀분석현시，교정년령、성별등인소후，여이상SBP조비교，정상고치Ⅰ기、정상고치Ⅱ기화고혈압조균위baPWV≥1400 cm/s적위험인소，OR치분별위2.70（95%CI：2.20～3.32）、4.56（95%CI：3.67～5.67）화13.51（95%CI：10.87～16.78）。결론SBP승고시baPWV증가적독립위험인소。
Objective To investigate the impact of different levels of systolic blood pressure on brachial-ankle pulse wave velocity(baPWV). Methods A total of 5 852 participants was selected with stratified random sampling from the 101 510 workers of Tangshan Kaiuan Company who had undergone a physical check-up program. 5 222 of them with integral data were recruited into this survey. According to SBP collected during the 2010-2011 health examination program,the population under observation was divided into four groups:optimal SBP(SBP<120 mmHg),high-normal blood pressure Ⅰ period(120 mmHg≤SBP<130 mmHg),high-normal blood pressure Ⅱ period (130 mmHg≤SBP<140 mmHg)and hypertension(SBP≥140 mmHg or SBP<140 mmHg but antihypertensive drug user). Multivariate logistic regression analysis was used to analyze the influence of different levels of systolic blood pressure on baPWV. Results 1)There were 3 132 males and 2 090 females in all the 5 222 participants with an average age of 55.1 years old. Their mean of baPWV was(1 587.57±400.71)cm/s,with the detection rates as 62%(baPWV≥1 400 cm/s). 2)The means of baPWV for the above groups of SBP were 1 322.19,1 456.27,1 544.78 and 1 827.77 cm/s, respectively,with detection rates of baPWV≥1 400 cm/s as 26.4%,49.3%,64.2% and 88.3%, respectively. 3)Results from the Multiple linear regression analysis revealed that β of SBP was 0.40,only ranking second,on age(0.48). 4)Data from the Multiple logistic regression analysis showed that after adjusting for age,gender and other risk factors,when compared to optimal SBP,factors as high-normal blood pressure Ⅰ period、high-normal blood pressure Ⅱ period and hypertension were risk factors for increasing baPWV,with OR values as 2.70(95%CI:2.20-3.32),4.56(95%CI:3.67-5.67)and 13.51(95%CI:10.87-16.78),respectively. Conclusion Higher SBP seemed an independent risk factor for the increase of baPWV.