CAJ | 학술논문

目的：分析2009-2012年6个省（直辖市）＜5岁儿童住院肺炎病例的病毒性病原，并描述其季节性分布。方法从北京、上海、重庆、广东、甘肃、四川6个省（直辖市）选取开展全国发热呼吸道症候群监测的8家医院，对其纳入的＜5岁儿童住院肺炎病例的人口统计学信息、临床症状和体征以及流感病毒、副流感病毒、呼吸道合胞病毒（RSV）、冠状病毒、偏肺病毒、博卡病毒、腺病毒的实验室检测结果，分不同年份、年龄组对儿童住院肺炎病例的病原谱进行分析，并描述各种病原阳性病例的季节性分布特征。结果2009-2012年，8家监测医院共纳入＜5岁儿童住院肺炎病例4508例，其中至少1种病毒检测阳性的2688例（阳性率59.6%）。RSV阳性率最高（21.3%），其次为副流感病毒（7.1%）和流感病毒（5.2%），博卡病毒、腺病毒和偏肺病毒阳性率分别为3.8%、3.6%和2.6%，冠状病毒最低（1.1%）。RSV、流感病毒、副流感病毒、博卡病毒和偏肺病毒的季节性明显。结论 RSV是我国＜5岁儿童住院肺炎病例的最常见病毒性病原，应在流行高峰季节采取预防控制措施以降低其对婴幼儿健康的严重危害。
목적：분석2009-2012년6개성（직할시）＜5세인동주원폐염병례적병독성병원，병묘술기계절성분포。방법종북경、상해、중경、엄동、감숙、사천6개성（직할시）선취개전전국발열호흡도증후군감측적8가의원，대기납입적＜5세인동주원폐염병례적인구통계학신식、림상증상화체정이급류감병독、부류감병독、호흡도합포병독（RSV）、관상병독、편폐병독、박잡병독、선병독적실험실검측결과，분불동년빈、년령조대인동주원폐염병례적병원보진행분석，병묘술각충병원양성병례적계절성분포특정。결과2009-2012년，8가감측의원공납입＜5세인동주원폐염병례4508례，기중지소1충병독검측양성적2688례（양성솔59.6%）。RSV양성솔최고（21.3%），기차위부류감병독（7.1%）화류감병독（5.2%），박잡병독、선병독화편폐병독양성솔분별위3.8%、3.6%화2.6%，관상병독최저（1.1%）。RSV、류감병독、부류감병독、박잡병독화편폐병독적계절성명현。결론 RSV시아국＜5세인동주원폐염병례적최상견병독성병원，응재류행고봉계절채취예방공제조시이강저기대영유인건강적엄중위해。
Objective To analyze the viral etiologies of hospitalized pneumonia patients aged less than five years in six provinces during 2009-2012,and to describe the seasonality of the detected viral etiologies. Methods Eight hospitals were selected in six provinces from a national acute respiratory infection surveillance network. Demographic information,clinical history and physical examination,and laboratory testing results of the enrolled hospitalized patients aged less than five years with pneumonia,including respiratory syncytial virus (RSV),human influenza virus, adenoviruses(ADV),human parainfluenza virus(PIV),human metapneumovirus(hMPV),human coronavirus(hCoV)and human bocavirus(hBoV)were analyzed. The viral etiology spectrum of the enrolled patients was analyzed by age-group,year,and seasonality of the detected viral etiologies were described. Results 4 508 hospitalized children less than five years old,with pneumonia from 8 hospitals were included,and 2 688(59.6%)patients were positive for at least one viral etiology. The most frequent detected virus was RSV(21.3%),followed by PIV(7.1%)and influenza(5.2%),hBoV (3.8%),ADV(3.6%)and hMPV(2.6%). The lowest positive rates in hCoV(1.1%). RSV,influenza, PIV,hBoV and hMPV all showed the nature of seasonality. Conclusion RSV was a most common viral etiology in the hospitalized young children less than 5 years of age with pneumonia. Prevention measures should be conducted to decrease its severe impact to the young infants and children in China.