CAJ | 학술논문

目的：评价左西孟旦治疗急性心肌梗死伴心力衰竭患者疗效.方法：40例急性心肌梗死伴心力衰竭患者随机分成治疗组（左西孟旦组）20例和对照组（多巴酚丁胺组）20例，左西孟旦组给予左西孟旦12.5mg加入10%葡萄糖500ml，初始10μg/kg，滴注时间为30分钟，之后以0.1μg/kg·min-1滴注，24小时滴注完成.多巴酚丁胺组给予多巴酚丁胺初始2.5μg/kg·min-1，1小时后增至5μg/kg·min-1，并持续滴注24小时，疗程一周，治疗前后测患者临床疗效及左室射血分数（LVEF）和脑钠肽（BNP）水平.结果：治疗组和对照组在年龄、性别、LVEF、BNP水平均无差异，用药前后在临床疗效及提高射血分数和降低脑钠肽水平方面有统计学差异（P<0.05）.结论：左西孟旦治疗急性心肌梗死伴心力衰竭患者疗效确切.
목적：평개좌서맹단치료급성심기경사반심력쇠갈환자료효.방법：40례급성심기경사반심력쇠갈환자수궤분성치료조（좌서맹단조）20례화대조조（다파분정알조）20례，좌서맹단조급여좌서맹단12.5mg가입10%포도당500ml，초시10μg/kg，적주시간위30분종，지후이0.1μg/kg·min-1적주，24소시적주완성.다파분정알조급여다파분정알초시2.5μg/kg·min-1，1소시후증지5μg/kg·min-1，병지속적주24소시，료정일주，치료전후측환자림상료효급좌실사혈분수（LVEF）화뇌납태（BNP）수평.결과：치료조화대조조재년령、성별、LVEF、BNP수평균무차이，용약전후재림상료효급제고사혈분수화강저뇌납태수평방면유통계학차이（P<0.05）.결론：좌서맹단치료급성심기경사반심력쇠갈환자료효학절.
Objective:To evaluate the effect of levosimendan on the patients with acute myocardial infarction(AMI) complicated with heart failure(HF). Methods:All the 40 patients with AMI and HF are randomly divided into treat-ment group(20 cases)and control group(20 cases). The treatment group was treated with levosimendan, 12.5mg levo-simendan was added into 500ml 10%glucose. The initial loading does was 10ug/kg and infused for 30min, followed by an infusion of 0.1ug/kg/min for 24h. The control group was treated with dobutamine, it was infused for 1h at an initial does of 2.5ug/kg/min, and for 23h at a continuous dose of 5ug/kg/min, the treatment course was 1 week. The level of left ventricular ejection fraction(LVEF)and brain natriuretic peptide(BNP)before and after treatment were measured and compared. Results:The age, gender, LVEF and BNP between treatment group and control group have no differ-ence. The clinical efficacy, LVEF increase and BNP decrease before and after treatment had difference(P< 0.05). Conclusion:Levosimendan has a good efficacy on patient with AMI and HF.