中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2013年
9期
1150-1152
,共3页
甲状腺相关眼病%干眼%眼表
甲狀腺相關眼病%榦眼%眼錶
갑상선상관안병%간안%안표
Thyroid associated ophthalmopathy%Dry eyes%Ocular surface
目的 分析甲状腺相关眼病(TAO)合并干眼症患者的临床特点.方法 将在上海市浦东新区公利医院眼科收治诊断为TAO并合并有干眼患者28例(55只眼)作为病例组,26名年龄、性别匹配的正常人作为对照组,对其临床资料进行详细记录包括甲状腺相关免疫指标,s-TSH,FT3,FT4,TAO活动性评分(GAS),泪液基础分泌试验(SIt)、泪膜破裂时间(BUT)、角膜荧光素染色评分等项目(FI),利用SPSS 13.0统计软件进行统计分析,免疫指标采用Mann-Whitney Test检验,其他指标用单因素方差分析.结果 28例患者中,TAO活动期患者12例(42.85％),非活动期患者16例(57.14％).活动期和非活动期甲亢眼病患者在甲状腺免疫指标的比较,差异有统计学意义s-TSH,P ＜0.01; FT3,P=0.013; FT4,P＜0.01.TAO患者的BUT比对照组显著的减少(P＜0.01),而Schirmer实验显示TAO患者和对照组相比差异无统计学意义.角膜荧光素染色评分在TAO活动期的患者和对照组比较,差异有统计学意义.结论 (1) TAO的泪液分泌正常.(2) TAO合并干眼是眼表的炎症导致泪膜不稳定引起的蒸发过强干眼.(3)活动期TAO患者的角膜受损.
目的 分析甲狀腺相關眼病(TAO)閤併榦眼癥患者的臨床特點.方法 將在上海市浦東新區公利醫院眼科收治診斷為TAO併閤併有榦眼患者28例(55隻眼)作為病例組,26名年齡、性彆匹配的正常人作為對照組,對其臨床資料進行詳細記錄包括甲狀腺相關免疫指標,s-TSH,FT3,FT4,TAO活動性評分(GAS),淚液基礎分泌試驗(SIt)、淚膜破裂時間(BUT)、角膜熒光素染色評分等項目(FI),利用SPSS 13.0統計軟件進行統計分析,免疫指標採用Mann-Whitney Test檢驗,其他指標用單因素方差分析.結果 28例患者中,TAO活動期患者12例(42.85％),非活動期患者16例(57.14％).活動期和非活動期甲亢眼病患者在甲狀腺免疫指標的比較,差異有統計學意義s-TSH,P ＜0.01; FT3,P=0.013; FT4,P＜0.01.TAO患者的BUT比對照組顯著的減少(P＜0.01),而Schirmer實驗顯示TAO患者和對照組相比差異無統計學意義.角膜熒光素染色評分在TAO活動期的患者和對照組比較,差異有統計學意義.結論 (1) TAO的淚液分泌正常.(2) TAO閤併榦眼是眼錶的炎癥導緻淚膜不穩定引起的蒸髮過彊榦眼.(3)活動期TAO患者的角膜受損.
목적 분석갑상선상관안병(TAO)합병간안증환자적림상특점.방법 장재상해시포동신구공리의원안과수치진단위TAO병합병유간안환자28례(55지안)작위병례조,26명년령、성별필배적정상인작위대조조,대기림상자료진행상세기록포괄갑상선상관면역지표,s-TSH,FT3,FT4,TAO활동성평분(GAS),루액기출분비시험(SIt)、루막파렬시간(BUT)、각막형광소염색평분등항목(FI),이용SPSS 13.0통계연건진행통계분석,면역지표채용Mann-Whitney Test검험,기타지표용단인소방차분석.결과 28례환자중,TAO활동기환자12례(42.85％),비활동기환자16례(57.14％).활동기화비활동기갑항안병환자재갑상선면역지표적비교,차이유통계학의의s-TSH,P ＜0.01; FT3,P=0.013; FT4,P＜0.01.TAO환자적BUT비대조조현저적감소(P＜0.01),이Schirmer실험현시TAO환자화대조조상비차이무통계학의의.각막형광소염색평분재TAO활동기적환자화대조조비교,차이유통계학의의.결론 (1) TAO적루액분비정상.(2) TAO합병간안시안표적염증도치루막불은정인기적증발과강간안.(3)활동기TAO환자적각막수손.
Objective To study the clinical involvement of the dry eye in patients affected by active and inactive thyroid associated ophthalmopathy (TAO).Methods The study included 28 TAO patients (55eyes) and 25 age and sex-matched healthy control subjects.Each participant underwent a full eye examination,including an evaluation of symptoms (clinical active score,CAS),tear secretion test (Schirmer Ⅰ test,SIt),tear break-up time (BUT) and fluorescent integral (FI).Their clinical manifestation were summarized and analyzed.The main indices of immunity were compared with Mann-Whitney Test.One way ANOVA with the least-significant difference (LSD) post hoc test revealed statistically significant differences between patients and controls in other evaluated parameters.Results Twelve (42.85％) of the 28 patients had active TAO.The main immune indices of TAO significant differences in active compared with inactive disease.Patients with TAO patients showed statistically significant decrease in BUT.There was no significant difference between TAO group and control in SIt.The injury of cornea was observed only in active patient of TAO.Conclusions TAO is complicated with evaporative dry eye secondly.Tear secretion is normal in TAO patients.The dry eye associated with TAO therefore seems to be mainly evaporative,due to the ocular sur face active inflammation.
