CAJ | 학술논문

目的探讨分析前列腺干细胞抗原(PSCA)第一外显子区(exon 1)基因多态性与肿瘤易感性是否存在相关性.方法使用PubMed数据库检索2011年5月以前的相关文献,按纳入标准搜索含有研究PSCA exon 1 C＞T多态性与肿瘤易感性相关的信息.结果根据检索条件,共有16306例肿瘤患者和17962例对照被纳入当前荟萃分析.分析表明PSCA exon 1 C＞T多态性增加了肿瘤的易感性,在肿瘤分层分析中发现PSCA突变型等位基因T显著增加了膀胱癌(P＜0.001,OR =1.09,95％CI:1.05～ 1.13)和胃癌(P =0.006,OR=1.21,95％CI:1.06～1.39)的易感性.结论 PSCA exon 1 C＞T多态性与膀胱癌和胃癌易感性存在相关性.
목적 탐토분석전렬선간세포항원(PSCA)제일외현자구(exon 1)기인다태성여종류역감성시부존재상관성.방법 사용PubMed수거고검색2011년5월이전적상관문헌,안납입표준수색함유연구PSCA exon 1 C＞T다태성여종류역감성상관적신식.결과 근거검색조건,공유16306례종류환자화17962례대조피납입당전회췌분석.분석표명PSCA exon 1 C＞T다태성증가료종류적역감성,재종류분층분석중발현PSCA돌변형등위기인T현저증가료방광암(P＜0.001,OR =1.09,95％CI:1.05～ 1.13)화위암(P =0.006,OR=1.21,95％CI:1.06～1.39)적역감성.결론 PSCA exon 1 C＞T다태성여방광암화위암역감성존재상관성.
Objectives Results from the related published studies on PSCA polymorphisms and cancer risk were somewhat underpowered in general.To assess the role of PSCA exon 1 C ＞ T variant in global cancer by meta-analysis.Methods A computerized literature search was conducted from PubMed and MEDLINE database.Two investigators extracted the data and reached a consensus on all items independently.Results The results showed evidence that PSCA exon 1 C ＞ T pymorphism was associated with increased total cancer risk in the overall comparisons.PSCA exon 1 C ＞T polymorphism has an increased risk in bladder cancer (P ＜0.001,OR =1.09,95％CI:1.05～1.13) and gastric cancer (P =0.006,OR=1.21,95％CI:1.06～1.39).Conclusions Thismeta-analysis showed evidence that PSCA exon 1 C ＞ T polymorphism was associated with bladder cancer and gastric cancer.