CAJ | 학술논문

目的观察布托啡诺用于妇科手术术后自控静脉镇痛（PCIA）的临床效果。方法120例妇科手术患者，随机分为布托啡诺组（B组）和舒芬太尼（S组）。B组用布托啡诺0.15mg/kg+生理盐水至100ml；S组选用舒芬太尼100μg+生理盐水至100ml。均采用PCA泵（100ml）以LCP模式（负荷剂量3ml+持续剂量2ml/h+PCA每次0.5ml）进行镇痛。观察术后1、4、8、24、48h患者VAS评分、Ramsay镇静评分，镇痛泵有效按压次数和不良反应发生情况。结果 B组与S组综合镇痛质量差异无统计学意义；B组皮肤瘙痒、嗜睡、呼吸抑制等发生率显著低于S组（P<0.01）。结论布托啡诺、舒芬太尼PCIA用于妇科手术术后镇痛均可获满意效果，但布托啡诺不良反应更少。
목적관찰포탁배낙용우부과수술술후자공정맥진통（PCIA）적림상효과。방법120례부과수술환자，수궤분위포탁배낙조（B조）화서분태니（S조）。B조용포탁배낙0.15mg/kg+생리염수지100ml；S조선용서분태니100μg+생리염수지100ml。균채용PCA빙（100ml）이LCP모식（부하제량3ml+지속제량2ml/h+PCA매차0.5ml）진행진통。관찰술후1、4、8、24、48h환자VAS평분、Ramsay진정평분，진통빙유효안압차수화불량반응발생정황。결과 B조여S조종합진통질량차이무통계학의의；B조피부소양、기수、호흡억제등발생솔현저저우S조（P<0.01）。결론 포탁배낙、서분태니PCIA용우부과수술술후진통균가획만의효과，단포탁배낙불량반응경소。
Objective To study clinical efficacy of butorphanol used for postoperative PICA in gynecological operation. Methods One hundred and twenty gynecological operation patients were randomly divided into butorphanol group(group B) and sufentanil group(group S). Group B, 0.15mg/kg butorphanol + normal saline to 100ml; group S, 100μg sufentanil+ normal saline to 100ml. Postoperative analgesia was provided by PCA pumb with LCP model (load dosage 3ml+lasting dosage 2ml+0.5ml/pertime). Observation of VAS score, Ramsay sedation score at 1、4、8、24 and 48h postoperatively in patients. The press times of PCA were recorded within 48 hours after surgery. Results Both groups did not show any significant difference in the analgesic effects. Complications as itching, sleeping and respiratory inhibition were less significantly in group B than in group S(P<0.01). Conclusions Either butorphanol or sufentanil is satisfied used for postoperative PCIA in gynecological operation patients, but the adverse effects are much higher with sufentanil than with butorphanol.