中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
12期
5366-5369
,共4页
黄斌%刘祥%程宇琪%白燕%吴俊瑶%王佳%向波%赵连生%许秀峰%李涛%马小红
黃斌%劉祥%程宇琪%白燕%吳俊瑤%王佳%嚮波%趙連生%許秀峰%李濤%馬小紅
황빈%류상%정우기%백연%오준요%왕가%향파%조련생%허수봉%리도%마소홍
精神分裂症%阿立哌唑%有效性%安全性
精神分裂癥%阿立哌唑%有效性%安全性
정신분렬증%아립고서%유효성%안전성
Schizophrenia%Aripiprazole%Efficacy%Safety
目的探索新一代非典型抗精神病药阿立哌唑口崩片治疗精神分裂症急性期的有效性和安全性。方法纳入符合中国精神障碍分类与诊断标准（ CCMD-3）中精神分裂症诊断的167例中重度患者作为研究对象。以阿立哌唑口崩片组作为阳性对照，研究采用随机、双盲双模拟、平行对照的方法。随机分为两组，用阿立哌唑片剂和阿立哌唑口崩片各治疗4周。在治疗前及治疗后2、4周用PANSS减分率判定疗效，采用不良反应量表（ TESS）评定不良反应。治疗前和治疗4周后均进行血常规、肝肾功能、血糖、血脂及心电图检查。采用SPSS 13.0统计软件对数据进行处理。结果治疗2周和4周后，阿立哌唑片剂组的有效率为2.38％和61.91％，阿立哌唑口崩片组的有效率为4.82％和63.86％，两组间差异均没有统计学意义。两种剂型不良反应主要为治疗后2周内，出现头晕、失眠、嗜睡、静坐不能和窦性心动过速等。结论阿立哌唑两种剂型具有同样的疗效与安全性。
目的探索新一代非典型抗精神病藥阿立哌唑口崩片治療精神分裂癥急性期的有效性和安全性。方法納入符閤中國精神障礙分類與診斷標準（ CCMD-3）中精神分裂癥診斷的167例中重度患者作為研究對象。以阿立哌唑口崩片組作為暘性對照，研究採用隨機、雙盲雙模擬、平行對照的方法。隨機分為兩組，用阿立哌唑片劑和阿立哌唑口崩片各治療4週。在治療前及治療後2、4週用PANSS減分率判定療效，採用不良反應量錶（ TESS）評定不良反應。治療前和治療4週後均進行血常規、肝腎功能、血糖、血脂及心電圖檢查。採用SPSS 13.0統計軟件對數據進行處理。結果治療2週和4週後，阿立哌唑片劑組的有效率為2.38％和61.91％，阿立哌唑口崩片組的有效率為4.82％和63.86％，兩組間差異均沒有統計學意義。兩種劑型不良反應主要為治療後2週內，齣現頭暈、失眠、嗜睡、靜坐不能和竇性心動過速等。結論阿立哌唑兩種劑型具有同樣的療效與安全性。
목적탐색신일대비전형항정신병약아립고서구붕편치료정신분렬증급성기적유효성화안전성。방법납입부합중국정신장애분류여진단표준（ CCMD-3）중정신분렬증진단적167례중중도환자작위연구대상。이아립고서구붕편조작위양성대조，연구채용수궤、쌍맹쌍모의、평행대조적방법。수궤분위량조，용아립고서편제화아립고서구붕편각치료4주。재치료전급치료후2、4주용PANSS감분솔판정료효，채용불량반응량표（ TESS）평정불량반응。치료전화치료4주후균진행혈상규、간신공능、혈당、혈지급심전도검사。채용SPSS 13.0통계연건대수거진행처리。결과치료2주화4주후，아립고서편제조적유효솔위2.38％화61.91％，아립고서구붕편조적유효솔위4.82％화63.86％，량조간차이균몰유통계학의의。량충제형불량반응주요위치료후2주내，출현두훈、실면、기수、정좌불능화두성심동과속등。결론아립고서량충제형구유동양적료효여안전성。
Objective To explore the efficacy and safety of aripiprazole orally disintegrating tablets in the treatment of acute schizophrenia .Methods We recruited 167 patients with schizophrenia , they were randomly divided into ariprazole common tablets treatment group and orally disintegrating tablets treatment group .Treatment efficacy were assessment using the Positive and Negative Syndrome Scale ( PANSS) reduction rate and the Treatment Emergent Symptom before treatment and after 2 weeks and 4 weeks treatment .Blood routine , liver and kidney function,blood glucose, blood lipid and ECG were tested, before treatment and after 4 weeks treatment. Results After 2 weeks and 4 weeks treatment,effective rate were 2.38% and 61.91% total in commen tablets group.4.82% and 63.86% in orally disintegrating tablets group , the difference between the two groups were not statistically significant .Adverse reactions mostly appeared within 2 weeks after the treatment in two dosage forms ,and mainly of them were dizziness ,insomnia,lethargy,akathisia and sinus tachycardia .Conclusion Aripiprazole orally disintegrating tablets and commen tablets have positive effect to improve psychiatric symptoms ,and show a good safety and tolerability .
