CAJ | 학술논문

目的通过检测14种食物成分的特异性IgG水平，研究食物不耐受与非酒精性脂肪肝、高脂血症的关系。方法选择2011～2013年青岛市1052名健康体检者，应用酶联免疫法（ ELISA ）检测血清14种食物特异性IgG抗体，采用SPSS 17.0软件对相关资料进行χ2检验、非条件Logistic回归分析。结果（1）1052名受检人群中牛奶不耐受（χ2＝70.457， P＜0.05）、螃蟹不耐受（χ2＝49.040， P＜0.05）、海虾不耐受（χ2＝20.692，P＜0.05）与非酒精性脂肪肝有关；牛奶不耐受与高脂血症有关（χ2＝24.871，P＜0.05）。（2）分别以非酒精性脂肪肝、高脂血症为因变量，年龄、性别、体重指数（ BMI）、海鲜和（或）非海鲜类食物不耐受为自变量进行多因素Logistic回归分析，结果显示非酒精性脂肪肝、高脂血症与海鲜、非海鲜类食物均不耐受组及海鲜类食物不耐受、非海鲜类食物耐受组比较，差异有统计学意义， OR 值（95％ CI ）分别为1.361（1.018～2.057）、1.372（1.040～6.071）、16.976（2.519～125.634）、2.674（1.481～37.087）。结论牛奶、螃蟹、海虾不耐受以及BMI与非酒精性脂肪肝有关，其中牛奶不耐受与非酒精性脂肪肝、高血脂均有关，海产品中螃蟹、海虾不耐受与非酒精性脂肪肝有关；海鲜类食物不耐受较非海鲜类食物不耐受更易导致非酒精性脂肪肝、高脂血症。因此，建议据食物不耐受检测结果加强饮食管理，预防非酒精性脂肪肝、高脂血症的发病。
목적통과검측14충식물성분적특이성IgG수평，연구식물불내수여비주정성지방간、고지혈증적관계。방법선택2011～2013년청도시1052명건강체검자，응용매련면역법（ ELISA ）검측혈청14충식물특이성IgG항체，채용SPSS 17.0연건대상관자료진행χ2검험、비조건Logistic회귀분석。결과（1）1052명수검인군중우내불내수（χ2＝70.457， P＜0.05）、방해불내수（χ2＝49.040， P＜0.05）、해하불내수（χ2＝20.692，P＜0.05）여비주정성지방간유관；우내불내수여고지혈증유관（χ2＝24.871，P＜0.05）。（2）분별이비주정성지방간、고지혈증위인변량，년령、성별、체중지수（ BMI）、해선화（혹）비해선류식물불내수위자변량진행다인소Logistic회귀분석，결과현시비주정성지방간、고지혈증여해선、비해선류식물균불내수조급해선류식물불내수、비해선류식물내수조비교，차이유통계학의의， OR 치（95％ CI ）분별위1.361（1.018～2.057）、1.372（1.040～6.071）、16.976（2.519～125.634）、2.674（1.481～37.087）。결론우내、방해、해하불내수이급BMI여비주정성지방간유관，기중우내불내수여비주정성지방간、고혈지균유관，해산품중방해、해하불내수여비주정성지방간유관；해선류식물불내수교비해선류식물불내수경역도치비주정성지방간、고지혈증。인차，건의거식물불내수검측결과가강음식관리，예방비주정성지방간、고지혈증적발병。
Objective To investigate the association between food intolerance and nonalcoholic fatty liver , hyperuricemia .Methods A total of 1052 Qingdao residents were recruited in this study from 2011 to 2013 .ELISA was used to test specific allergic IgG antibodies .Chi-square test and Logistic regression were used for data analysis by SPSS 17.0 .Results ( 1 ) In the 1052 residents , there were significant difference between food intolerance and nonalcoholic fatty liver:milk intolerance and nonalcoholic fatty liver (χ2 =70.457,P<0.05),Crab intolerance and nonalcoholic fatty liver (χ2 =49.040 ,P<0.05 );Prawns intolerance and nonalcoholic fatty liver (χ2 =20.692 , P<0.05 );There was significant difference between food intolerance and hyperlipidemia : milk intolerance and hyperlipidemia(χ2 =24.871,P<0.05);(2)In logistic regression analysis,there was significant difference between nonalcoholic fatty liver and sea food intolerance ,non sea food intolerance ,the odds ratio was 1.361(1.018-2.057);Nonalcoholic fatty liver and sea food intolerance ,non sea food intolerance:1.372 (1.040-6.071 );Hyperlipidemia and sea food intolerance,non sea food tolerance:16.976(2.519-125.634);Hyperlipidemia and sea food intolerance ,non sea food tolerance:2.674 (1.481-37.087).Conclusion There is correlation between milk,crab,eggs,Prawns intolerance ,BMI and nonalcoholic fatty liver ,hyperuricemia;The risk of suffering nonalcoholic fatty liver is larger in sea food intolerance than non sea food;Sea food intolerance result in nonalcoholic fatty liver , hyperlipidemia more easily than non sea food .Therefore , food adjustment might be useful in the prevention and treatment of metabolic disease according to the test results the food intolerance .