中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2013年
16期
60-61
,共2页
不孕不育%染色体%核型异常
不孕不育%染色體%覈型異常
불잉불육%염색체%핵형이상
infertility patients%chromosome%abnormal phenotype
目的探讨不孕不育患者的表型与染色体核型异常的关系，分析染色体畸变的频率分布和类型。方法选自2009年3月-2011年9月于我院接受治疗的840例不孕不育患者，进行细胞遗传学检查，对核型异常的染色体进行临床分析。结果840例患者经分析出现106例核型异常染色体，检出率为12.62%，其中常染色体异常51例，占48.11%，性染色体异常55例，占51.89%。临床表现多为性生殖器发育不良、原发或继发闭经、自然流产、胚胎停育、无精、少精等症状。结论染色体核型异常是导致不孕不育的重要原因，患者若久治不愈，可检查染色体的核型，以尽早发现不孕原因，对症治疗。
目的探討不孕不育患者的錶型與染色體覈型異常的關繫，分析染色體畸變的頻率分佈和類型。方法選自2009年3月-2011年9月于我院接受治療的840例不孕不育患者，進行細胞遺傳學檢查，對覈型異常的染色體進行臨床分析。結果840例患者經分析齣現106例覈型異常染色體，檢齣率為12.62%，其中常染色體異常51例，佔48.11%，性染色體異常55例，佔51.89%。臨床錶現多為性生殖器髮育不良、原髮或繼髮閉經、自然流產、胚胎停育、無精、少精等癥狀。結論染色體覈型異常是導緻不孕不育的重要原因，患者若久治不愈，可檢查染色體的覈型，以儘早髮現不孕原因，對癥治療。
목적탐토불잉불육환자적표형여염색체핵형이상적관계，분석염색체기변적빈솔분포화류형。방법선자2009년3월-2011년9월우아원접수치료적840례불잉불육환자，진행세포유전학검사，대핵형이상적염색체진행림상분석。결과840례환자경분석출현106례핵형이상염색체，검출솔위12.62%，기중상염색체이상51례，점48.11%，성염색체이상55례，점51.89%。림상표현다위성생식기발육불량、원발혹계발폐경、자연유산、배태정육、무정、소정등증상。결론염색체핵형이상시도치불잉불육적중요원인，환자약구치불유，가검사염색체적핵형，이진조발현불잉원인，대증치료。
Objective: To investigate the relationship between chromosome abnormality and their phenotype,and analyze the abnormal phenotype and frequency distribution of abnormal chromosome.Methods: Among 840 patients consulted in our hospital from March 2009 to September 2011,clinical analysis of chromosome karyotype were conducted in abnormaI chromosome patients Results: 106 cases were karyotype abnormal chromosome in 840 patients, the detection rate was 12.62%.The numbers of euchromosome abnormalities were 51(48.11).The number of sex chromosome abnormalities were 55(51.89).The clinical manifestations were sexual genital hypoplasia , primary or secondary amenorrhea , spontaneous abortion , embryonic stop infertility,azoospermia and oligospermia .Conclusion:Abnormal karyotype is an important cause of infertility patients permanently, checking chromosome karyotype may detect the causes of infertility early,be symptomatic treatment.
