中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2013年
17期
205-206
,共2页
早发胃癌%STR%易感基因
早髮胃癌%STR%易感基因
조발위암%STR%역감기인
Gastric cancer%STR%Sensitive genes
目的讨论早发胃癌与15个STR(短串联重复序列)位点的关联。方法胃癌组为住院患者共10例,男5例,女5例;STR对照组是100位无关健康个体,男女各50例。STR采用PCR和五色荧光自动检测技术进行检测,STR包括D8S1179、D21S11、D7S820、CSF1PO、D3S1358、D5S818、D13S317、D16S539、D2S1338、D19S433、VWA、D12S391、D18S51、D6S1043、FGA。结果 STR中CSF1PO-10.2、V W A-17、D6S1043-17位点的频数分别为0.100、0.450、0.150,对照组频数分别为0.000、0.200、0.030,这三项存在显著性差异(P<0.05);其他位点没有显著性差异(P>0.05)。结论 STR中CSF1PO-10.2、VWA-17、D6S1043-17位点的频率高于对照组,其附近可能有早发胃癌的易感基因。
目的討論早髮胃癌與15箇STR(短串聯重複序列)位點的關聯。方法胃癌組為住院患者共10例,男5例,女5例;STR對照組是100位無關健康箇體,男女各50例。STR採用PCR和五色熒光自動檢測技術進行檢測,STR包括D8S1179、D21S11、D7S820、CSF1PO、D3S1358、D5S818、D13S317、D16S539、D2S1338、D19S433、VWA、D12S391、D18S51、D6S1043、FGA。結果 STR中CSF1PO-10.2、V W A-17、D6S1043-17位點的頻數分彆為0.100、0.450、0.150,對照組頻數分彆為0.000、0.200、0.030,這三項存在顯著性差異(P<0.05);其他位點沒有顯著性差異(P>0.05)。結論 STR中CSF1PO-10.2、VWA-17、D6S1043-17位點的頻率高于對照組,其附近可能有早髮胃癌的易感基因。
목적토론조발위암여15개STR(단천련중복서렬)위점적관련。방법위암조위주원환자공10례,남5례,녀5례;STR대조조시100위무관건강개체,남녀각50례。STR채용PCR화오색형광자동검측기술진행검측,STR포괄D8S1179、D21S11、D7S820、CSF1PO、D3S1358、D5S818、D13S317、D16S539、D2S1338、D19S433、VWA、D12S391、D18S51、D6S1043、FGA。결과 STR중CSF1PO-10.2、V W A-17、D6S1043-17위점적빈수분별위0.100、0.450、0.150,대조조빈수분별위0.000、0.200、0.030,저삼항존재현저성차이(P<0.05);기타위점몰유현저성차이(P>0.05)。결론 STR중CSF1PO-10.2、VWA-17、D6S1043-17위점적빈솔고우대조조,기부근가능유조발위암적역감기인。
Objective Discuss early attack patient with gastric cancer and its association with 15 STR Loci. Methods The early gastric cancer patients consisted of 10 hospitalized cancer patients including 5 males and 5 females . STR loci were tested by means of PCR and five-color fluorescent automatic detection, which included D8S1179, D21S11, D7S820, CSF1PO, D3S1358, D5S818, D13S317, D16S539, D2S1338, D19S433, VWA, D12S391, D18S51, D6S1043, FGA. Results The loci frequencies of STRs CSF1PO-10.2, VWA-17, D6S1043-17 were 0.100,0.450 and 0.150 respectively and those in the control group were 0.000, 0.200, 0.030 respectively.There was significant difference (P<0.05) in these three items and no significant difference in the other items(P >0.05). Conclusion The loci frequencies of STRs CSF1PO-10.2,VWA-17, D6S1043-17 are higher than those in the control group, so there might be sensitive genes nearby to early gastric cancer.