中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
30期
127-128
,共2页
乙型肝炎病毒%临床表型%基因型
乙型肝炎病毒%臨床錶型%基因型
을형간염병독%림상표형%기인형
Hepatitis b Virus%Clinical phenotype%Genotype
目的：对乙型肝炎病毒（HBV）在人体内的分散情况进行调查，然后讨论它和感染临床表型是否有关系。方法：对PCR进行测序，测序之前先对其进行扩增，然后分析300例乙肝病毒感染者的HBV基因型，对HBV的基因型和临床表型之间的关系用t检验法和字2检验法分析。结果：在300例的病毒感染者中，含有B基因型的患者180例，占60%，含有C基因型的患者120例，占40%。B基因型患者年龄（29.5±9.8）岁明显高于C基因型患者（35.2±11.4）岁，差异有统计学意义（P<0.05）；在这些男女受访患者中，HBV的基因型分散情况差异无统计学意义（P>0.05）。C基因型在无症状病毒携带者的比例是31.2%，在慢性乙肝患者中比例为30.2%，明显低于肝癌患者的58.6%和肝硬化患者的60.0%，差异均有统计学意义（P<0.05）；B基因型HBeAg阳性率55.6%明显低于C基因型的71.7%，差异有统计学意义（P<0.05）；B基因型患者血清的HBV-DNA含量（5.62±0.92）log值明显低于C基因型患者的（5.98±0.76）log值，差异有统计学意义（P<0.05）。结论：临床患者的身体状况和HBV的基因型有着密不可分的关系。从患者的年纪、HBeAg阳性比例和病毒水平来看，C基因型患者明显比B基因型多，因此C基因型患者的病情很可能进一步转为肝硬化，甚至是肝癌。
目的：對乙型肝炎病毒（HBV）在人體內的分散情況進行調查，然後討論它和感染臨床錶型是否有關繫。方法：對PCR進行測序，測序之前先對其進行擴增，然後分析300例乙肝病毒感染者的HBV基因型，對HBV的基因型和臨床錶型之間的關繫用t檢驗法和字2檢驗法分析。結果：在300例的病毒感染者中，含有B基因型的患者180例，佔60%，含有C基因型的患者120例，佔40%。B基因型患者年齡（29.5±9.8）歲明顯高于C基因型患者（35.2±11.4）歲，差異有統計學意義（P<0.05）；在這些男女受訪患者中，HBV的基因型分散情況差異無統計學意義（P>0.05）。C基因型在無癥狀病毒攜帶者的比例是31.2%，在慢性乙肝患者中比例為30.2%，明顯低于肝癌患者的58.6%和肝硬化患者的60.0%，差異均有統計學意義（P<0.05）；B基因型HBeAg暘性率55.6%明顯低于C基因型的71.7%，差異有統計學意義（P<0.05）；B基因型患者血清的HBV-DNA含量（5.62±0.92）log值明顯低于C基因型患者的（5.98±0.76）log值，差異有統計學意義（P<0.05）。結論：臨床患者的身體狀況和HBV的基因型有著密不可分的關繫。從患者的年紀、HBeAg暘性比例和病毒水平來看，C基因型患者明顯比B基因型多，因此C基因型患者的病情很可能進一步轉為肝硬化，甚至是肝癌。
목적：대을형간염병독（HBV）재인체내적분산정황진행조사，연후토론타화감염림상표형시부유관계。방법：대PCR진행측서，측서지전선대기진행확증，연후분석300례을간병독감염자적HBV기인형，대HBV적기인형화림상표형지간적관계용t검험법화자2검험법분석。결과：재300례적병독감염자중，함유B기인형적환자180례，점60%，함유C기인형적환자120례，점40%。B기인형환자년령（29.5±9.8）세명현고우C기인형환자（35.2±11.4）세，차이유통계학의의（P<0.05）；재저사남녀수방환자중，HBV적기인형분산정황차이무통계학의의（P>0.05）。C기인형재무증상병독휴대자적비례시31.2%，재만성을간환자중비례위30.2%，명현저우간암환자적58.6%화간경화환자적60.0%，차이균유통계학의의（P<0.05）；B기인형HBeAg양성솔55.6%명현저우C기인형적71.7%，차이유통계학의의（P<0.05）；B기인형환자혈청적HBV-DNA함량（5.62±0.92）log치명현저우C기인형환자적（5.98±0.76）log치，차이유통계학의의（P<0.05）。결론：림상환자적신체상황화HBV적기인형유착밀불가분적관계。종환자적년기、HBeAg양성비례화병독수평래간，C기인형환자명현비B기인형다，인차C기인형환자적병정흔가능진일보전위간경화，심지시간암。
Objective:To investigate the dispersion of HBV in the human body and discuss whether it is related to the infection in clinical phenotype.Method:A sequencing of PCR was conducted after the amplification of PCR,then the HBV genotype of 300 HBV patients was analyzed and t and χ2 test methods were applied to analyze the relationship between the genotype and clinical phenotype of HBV.Result:Among the 300 HBV patients,patients with B genotype had 180 patients,accounted for about 60%;those with C genotype had 120 patients,accounted for 40%.Patients with B genotype(29.5±9.8)years old was obviously younger than those with C genotype(35.2±11.4)years old,the difference was statistically significant (P<0.05);there’s no statistical significance in the difference of HBV genotype dispersion caused by gender difference(P>0.05).C genotype was 31.2%in chronic asymptomatic HBV carriers proportion,in patients with chronic hepatitis B was 30.2%,significantly lower than the 58.6%patients with hepatocellular carcinoma and the 60%patients with liver cirrhosis,the differences were statistically significant(P<0.05);the positive rate of B genotype and HBeAg(55.6%)was obviously lower than that of C genotype(71.7%),the difference was statistically significant(P<0.05);the HBV-DNA content logo value of the serum of patients with B genotype(5.62±0.92)was apparently lower than that of patients with C genotype(5.98±0.76),the difference was statistically significant(P<0.05).Conclusion:Physical condition of clinical patients has an inseparable relationship with HBV genotype. When it comes to the age,HBeAg positive ratio and virus level of the patients,those of the patients with C genotype are obviously more than those of patients with B genotype,thus,conditions of patients with C genotype will probably turn into cirrhosis or even liver cancer.
