检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2013年
17期
2236-2237,2239
,共3页
紫癜性肾炎%胱抑素C%免疫透射比浊法
紫癜性腎炎%胱抑素C%免疫透射比濁法
자전성신염%광억소C%면역투사비탁법
purpura nephritis%cystatin C%immunity transmission turbidity
目的通过对紫癜性肾炎（HSPN）患儿血清胱抑素C（Cys C）水平的检测，探讨血清Cys C水平检测在HSPN早期诊断的临床应用价值。方法在日立7600-020全自动生化分析仪上对实验组和对照组的血清标本采用免疫透射比浊法检测Cys C含量，同时对血清样本中免疫球蛋白IgA、IgG、IgM和肾功能相关的血清学指标进行检测。结果实验组血清Cys C、IgA、尿素（UREA）和肌酐（Cre）含量明显高于对照组，差异有统计学意义或高度统计学意义（P＜0．05或 P＜0．01）；血清IgG和IgM 含量检测结果两组比较，差异无统计学意义（P＞0．05）；HSPN患儿不同病期血清中Cys C、IgA、UREA和Cre的含量呈递增性升高，趋势呈正相关性，但血清Cys C的相关性优越其他项目。其检测结果在轻型紫癜性肾炎、慢性紫癜肾炎综合征、紫癜肾病综合征和急进性紫癜性肾炎疾病中明显高于急性紫癜肾炎综合征，与其比较，差异有统计学意义（P＜0．05）。结论血清Cys C水平检测有助于HSPN的早期诊断及临床的疗效观察，能为临床医生提供有价值的治疗依据。
目的通過對紫癜性腎炎（HSPN）患兒血清胱抑素C（Cys C）水平的檢測，探討血清Cys C水平檢測在HSPN早期診斷的臨床應用價值。方法在日立7600-020全自動生化分析儀上對實驗組和對照組的血清標本採用免疫透射比濁法檢測Cys C含量，同時對血清樣本中免疫毬蛋白IgA、IgG、IgM和腎功能相關的血清學指標進行檢測。結果實驗組血清Cys C、IgA、尿素（UREA）和肌酐（Cre）含量明顯高于對照組，差異有統計學意義或高度統計學意義（P＜0．05或 P＜0．01）；血清IgG和IgM 含量檢測結果兩組比較，差異無統計學意義（P＞0．05）；HSPN患兒不同病期血清中Cys C、IgA、UREA和Cre的含量呈遞增性升高，趨勢呈正相關性，但血清Cys C的相關性優越其他項目。其檢測結果在輕型紫癜性腎炎、慢性紫癜腎炎綜閤徵、紫癜腎病綜閤徵和急進性紫癜性腎炎疾病中明顯高于急性紫癜腎炎綜閤徵，與其比較，差異有統計學意義（P＜0．05）。結論血清Cys C水平檢測有助于HSPN的早期診斷及臨床的療效觀察，能為臨床醫生提供有價值的治療依據。
목적통과대자전성신염（HSPN）환인혈청광억소C（Cys C）수평적검측，탐토혈청Cys C수평검측재HSPN조기진단적림상응용개치。방법재일립7600-020전자동생화분석의상대실험조화대조조적혈청표본채용면역투사비탁법검측Cys C함량，동시대혈청양본중면역구단백IgA、IgG、IgM화신공능상관적혈청학지표진행검측。결과실험조혈청Cys C、IgA、뇨소（UREA）화기항（Cre）함량명현고우대조조，차이유통계학의의혹고도통계학의의（P＜0．05혹 P＜0．01）；혈청IgG화IgM 함량검측결과량조비교，차이무통계학의의（P＞0．05）；HSPN환인불동병기혈청중Cys C、IgA、UREA화Cre적함량정체증성승고，추세정정상관성，단혈청Cys C적상관성우월기타항목。기검측결과재경형자전성신염、만성자전신염종합정、자전신병종합정화급진성자전성신염질병중명현고우급성자전신염종합정，여기비교，차이유통계학의의（P＜0．05）。결론혈청Cys C수평검측유조우HSPN적조기진단급림상적료효관찰，능위림상의생제공유개치적치료의거。
Objective To explore the application value of serum cystatin C (Cys C) detection for the early di-agnosis of Henoch-schonlein purpura nephritis (HSPN ) in children .Methods Serum levels of Cys C in experiment group and control group were detected on HITACHI 7600-020 automatic biochemical analyzer by using immune transmission turbidity method .Immunoglobulin (Ig) ,including IgA ,IgG and IgM ,UREA and creatinine (CREA) were also detected .Results Levels of Cys C ,IgA ,IgA ,UREA and CREA in experiment group were higher than control group (P< 0 .05 or P<0 .01) ,but the difference of IgG and IgM were not statistically significant (P>0 .05) .Levels of Cys C ,IgA ,UREA and CREA were positively correlated with illness stage ,and the correlation of Cys C with illness was superior to the other indicators .Cys C levels in children with mild HSPN ,chronic HSPN syndrome ,prupura nephrotic syndrome and radical HSPN were significantly higher than that in children with acute HSPN syndrome (P<0 .05) .Conclusion Serum Cys C detection might be useful for the early detection and thera-peutic effect evaluation of HSPN ,and could provide valuable basis for clinical treatment .
