CAJ | 학술논문

目的探讨血清肿瘤标志物检测在盆腔良恶性妇科肿瘤诊断和鉴别诊断中的价值。方法对108例健康女性、96例妇科良性肿瘤患者和60例妇科恶性肿瘤患者采用微粒子化学发光分析，检测癌胚抗原（CEA ）、甲胎蛋白（AFP）、糖类抗原（CA）125、CA153和CA199浓度，并对结果进行统计学分析。结果恶性肿瘤组CA125、CA199、CA153浓度明显高于健康对照组和良性肿瘤组，差异具有统计学意义（P＜0．01），良性肿瘤组CA125、CA199浓度高于健康对照组，其中CA199差异具有统计学意义（P＜0．05）。CEA、AFP在3组中浓度差异无统计学意义（P＞0．05）。CA125、CA199在良、恶性妇科肿瘤中均有较高的阳性率。结论联合检测CA125、CA199、CA153浓度有助于良、恶性妇科肿瘤的诊断和鉴别诊断。
목적탐토혈청종류표지물검측재분강량악성부과종류진단화감별진단중적개치。방법대108례건강녀성、96례부과량성종류환자화60례부과악성종류환자채용미입자화학발광분석，검측암배항원（CEA ）、갑태단백（AFP）、당류항원（CA）125、CA153화CA199농도，병대결과진행통계학분석。결과악성종류조CA125、CA199、CA153농도명현고우건강대조조화량성종류조，차이구유통계학의의（P＜0．01），량성종류조CA125、CA199농도고우건강대조조，기중CA199차이구유통계학의의（P＜0．05）。CEA、AFP재3조중농도차이무통계학의의（P＞0．05）。CA125、CA199재량、악성부과종류중균유교고적양성솔。결론연합검측CA125、CA199、CA153농도유조우량、악성부과종류적진단화감별진단。
Objective To investigate the value of tumor markers for the diagnosis and differential diagnosis of benign and malignant gynecologic neoplasms .Methods Serum carcino-embryonic antigen (CEA) ,alpha fetoprotein (AFP) ,carbohydrate antigen (CA) 125 (CA125) ,CA153 and CA199 were detected in 108 cases health women (healthy control group) ,96 cases of benign gynecologic neoplasms and 60 cases with malignant gynecologic neo-plasms by using chemoluminescence method .Results Concentrations of CA125 ,CA199 and CA153 in malignant gy-necologic neoplasms group were significant higher than benign and healthy control group (P<0 .01) ,and concentra-tions of CA125 and CA199 in benign gynecologic neoplasms group were higher than healthy control group ,but only the difference of CA199 was significant (P<0 .05) .There were no significant differences of CEA and AFP levels a-mong the three groups (P>0 .05) .Positive rates of CA125 and CA199 were relatively high in patients with benign or malignant gynecologic neoplasms .Conclusion Combined detection of CA125 ,CA199 and CA153 might be useful for the diagnosis and differential diagnosis of benign and malignant gynecologic neoplasms .