CAJ | 학술논문

目的：分析脐带血乙肝病毒DNA（HBV-DNA）定量检测在对慢性乙型肝炎产妇自发性早产及胎儿垂直感染的影响。方法69例围产期慢性乙型肝炎产妇接受血液学及病毒学评估后，将56例患者纳入研究，分析其脐带血HBV-DNA与SPB发生的关系，并分析脐带血HBV-DNA与产妇HBV-DNA水平的相关关系，分析12个月后接种完疫苗的56例婴儿HBV感染与脐带血及母亲HBV-DNA水平的相关性。结果56例产妇中，共有13例产妇发生SPB，SPB的发生与脐带血中HBV-DNA水平呈明显相关性（r=0.679，P＜0.01）。脐带血中HBV-DNA水平与产妇HBV-DNA水平呈明显相关性（r=0.498，P＜0.01）。而脐带血及产妇HBV-DNA水平并不增加婴儿乙型肝炎感染的风险。结论脐带血中HBV-DNA的表达与慢性乙型肝炎产妇SPB发生明显相关，但脐带血及产妇HBV-DNA水平并不增加婴儿乙型肝炎感染的风险。
목적：분석제대혈을간병독DNA（HBV-DNA）정량검측재대만성을형간염산부자발성조산급태인수직감염적영향。방법69례위산기만성을형간염산부접수혈액학급병독학평고후，장56례환자납입연구，분석기제대혈HBV-DNA여SPB발생적관계，병분석제대혈HBV-DNA여산부HBV-DNA수평적상관관계，분석12개월후접충완역묘적56례영인HBV감염여제대혈급모친HBV-DNA수평적상관성。결과56례산부중，공유13례산부발생SPB，SPB적발생여제대혈중HBV-DNA수평정명현상관성（r=0.679，P＜0.01）。제대혈중HBV-DNA수평여산부HBV-DNA수평정명현상관성（r=0.498，P＜0.01）。이제대혈급산부HBV-DNA수평병불증가영인을형간염감염적풍험。결론제대혈중HBV-DNA적표체여만성을형간염산부SPB발생명현상관，단제대혈급산부HBV-DNA수평병불증가영인을형간염감염적풍험。
Objective To analyze the impact of quantitative determination of HBV-DNA in umbilical blood on spontaneous preterm birth(SPB) and fetal vertical infection of maternity with chronic hepatitis B. Methods After hematology and virology assessment of 69 maternities with perinatal chronic hepatitis B,56 patients were included in the study.The relationships between HBV-DNA in umbilical blood and the occurrence of SPB,the correlation of HBV-DNA level in umbilical blood and HBV-DNA level of maternities,and the correlation of HBV infection of 56 infants with vaccination vaccine after 12 months and HBV-DNA level in umbilical blood and maternities were analyzed. Results In 56 maternities,13 maternities occur SPB,the occurrence of SPB and HBV-DNA level in umbilical blood were significantly correlated(r=0.679,P < 0.01).The HBV-DNA level in umbilical blood and maternities were significantly correlated(r=0.498,P<0.01).But the HBV-DNA level in umbilical blood and maternities did not increase the risk of infant hepatitis B infection. Conclusion The expression of HBV-DNA in umbilical blood and the SPB occurrence of maternity with chronic hepatitis B is significantly correlated,but the HBV-DNA level in umbilical blood and maternities don't increase the risk of infant hepatitis B infection.