中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2013年
18期
95-97
,共3页
小儿%上呼吸道感染%炎琥宁注射液
小兒%上呼吸道感染%炎琥寧註射液
소인%상호흡도감염%염호저주사액
Children%Upper respiratory infection%Yanhuning injection
目的:评价大环内脂类抗生素或β-内酰胺类加抗病毒药物如利巴韦林与炎琥宁注射液辅助治疗小儿上呼吸道感染(AURI)的临床效果。方法择选我院AURI共50例(其中男28例,女22例),随机均分为两组,对照组25例,治疗组25例。对照组为常规治疗,治疗组为炎琥宁注射液加常规治疗,疗程均为3d。炎琥宁注射液(5~10)mg/kg·d加入5%葡萄糖50~100mL静脉滴注,1.5次/d左右静脉滴注。认真观察对照组与实验组患儿治疗后的症状缓解状况,然后对两组患儿血液常规检查进行对比分析,最后根据疗效评价标准对两组疗效进行评价。结果对照组治疗有效率为68.00%,治疗组治疗有效率为96.00%,两组治疗有效率比较差异有统计学意义( P<0.05)。经统计学检验,治疗组的疗效显著优于对照组为,差异有统计学意义(P<0.05)。本研究患儿的治疗中对照组患者共出现3例(12.0%)胃肠道不适者,3例患儿出现皮疹(12.0%),其他2例(8.0%),不良反应率为32.0%;治疗组1例(4.0%)治疗组皮疹,无其他不良反应,不良反应率为4.0%。治疗组不良反应率较对照组明显降低。治疗组发热、鼻塞流涕、白细胞计数等恢复正常的时间比对照组短,差异有统计学意义(P<0.05)。结论常规治疗方法加中成药炎琥宁注射液治疗小儿上呼吸道感染有显著疗效,同时还可以大大降低目前我国的基层医疗机构滥用抗生素。该药的治疗效果安全可靠,见效快,不良反应少的优点,值得临床推广用药。
目的:評價大環內脂類抗生素或β-內酰胺類加抗病毒藥物如利巴韋林與炎琥寧註射液輔助治療小兒上呼吸道感染(AURI)的臨床效果。方法擇選我院AURI共50例(其中男28例,女22例),隨機均分為兩組,對照組25例,治療組25例。對照組為常規治療,治療組為炎琥寧註射液加常規治療,療程均為3d。炎琥寧註射液(5~10)mg/kg·d加入5%葡萄糖50~100mL靜脈滴註,1.5次/d左右靜脈滴註。認真觀察對照組與實驗組患兒治療後的癥狀緩解狀況,然後對兩組患兒血液常規檢查進行對比分析,最後根據療效評價標準對兩組療效進行評價。結果對照組治療有效率為68.00%,治療組治療有效率為96.00%,兩組治療有效率比較差異有統計學意義( P<0.05)。經統計學檢驗,治療組的療效顯著優于對照組為,差異有統計學意義(P<0.05)。本研究患兒的治療中對照組患者共齣現3例(12.0%)胃腸道不適者,3例患兒齣現皮疹(12.0%),其他2例(8.0%),不良反應率為32.0%;治療組1例(4.0%)治療組皮疹,無其他不良反應,不良反應率為4.0%。治療組不良反應率較對照組明顯降低。治療組髮熱、鼻塞流涕、白細胞計數等恢複正常的時間比對照組短,差異有統計學意義(P<0.05)。結論常規治療方法加中成藥炎琥寧註射液治療小兒上呼吸道感染有顯著療效,同時還可以大大降低目前我國的基層醫療機構濫用抗生素。該藥的治療效果安全可靠,見效快,不良反應少的優點,值得臨床推廣用藥。
목적:평개대배내지류항생소혹β-내선알류가항병독약물여리파위림여염호저주사액보조치료소인상호흡도감염(AURI)적림상효과。방법택선아원AURI공50례(기중남28례,녀22례),수궤균분위량조,대조조25례,치료조25례。대조조위상규치료,치료조위염호저주사액가상규치료,료정균위3d。염호저주사액(5~10)mg/kg·d가입5%포도당50~100mL정맥적주,1.5차/d좌우정맥적주。인진관찰대조조여실험조환인치료후적증상완해상황,연후대량조환인혈액상규검사진행대비분석,최후근거료효평개표준대량조료효진행평개。결과대조조치료유효솔위68.00%,치료조치료유효솔위96.00%,량조치료유효솔비교차이유통계학의의( P<0.05)。경통계학검험,치료조적료효현저우우대조조위,차이유통계학의의(P<0.05)。본연구환인적치료중대조조환자공출현3례(12.0%)위장도불괄자,3례환인출현피진(12.0%),기타2례(8.0%),불량반응솔위32.0%;치료조1례(4.0%)치료조피진,무기타불량반응,불량반응솔위4.0%。치료조불량반응솔교대조조명현강저。치료조발열、비새류체、백세포계수등회복정상적시간비대조조단,차이유통계학의의(P<0.05)。결론상규치료방법가중성약염호저주사액치료소인상호흡도감염유현저료효,동시환가이대대강저목전아국적기층의료궤구람용항생소。해약적치료효과안전가고,견효쾌,불량반응소적우점,치득림상추엄용약。
Objective To evaluate the clinical effect of macrolide antibiotic or β-lactam antibiotic and antiviral drugs such as ribavirin and yanhuning injection in adjuvant treatment of children acute upper respiratory infection (AURI). Methods 50 children with AURI in our hospital, of which 28 boys and 22 girls, were randomly divided into two groups, 25 patients in the control group and 25 patients in the treatment group. The patients in the control group received conventional treatment for three days, while the patients in the treatment group received yanhuning injection and conventional treatment for three days. The usage of yanhuning injection was 5 ~ 10mg/(kg·d)yanhuning injection diluted with 50~100mL 5%glucose injection intravenous drip 1.5 times daily. The symptom relief of patients after the treatment in the control group and the treatment group were carefully observed, blood routine examination of two groups were compared and analyzed, then the efficacy of two groups were evaluated according to efficacy evaluation standards. Results The treatment effective rate of the control group was 68.00%, the treatment effective rate of the treatment group was 96.00%, there was significant difference in the treatment effective rate between two groups(P < 0.05). The efficacy of the treatment group was statistically better than that of the control group, the difference was statistically significant (P<0.05). In the treatment of patients, there were 3 cases (12.0%) with gastrointestinal discomfort, 3 cases (12.0%) with rash, 2 cases (8.0%) with other disease in the control group, the adverse reaction rate was 32.0%; there were 1 case (4.0%) with rash, no other adverse reactions, the adverse reaction rate was 4.0%. The adverse reaction rate of the treatment group was significantly lower than that of the control group. The time to normalization of fever, stuffy and running nose, white blood cell count in the treatment group were shorter than those in the control group, the differences were statistically significant(P<0.05). Conclusion Conventional treatment methods and yanhuning injection of Chinese patent drug in treatment of children upper respiratory infection has significant effect, but can also greatly reduce the misuse of antibiotics in basic medical institutions in China. The drug has the merits such as safe and reliable therapeutic effect, rapid onset, fewer adverse reactions, and it is worthy of clinical popularization and application.