CAJ | 학술논문

目的：比较单肺通气（OLV）后，家兔双侧肺内炎性因子的变化，评价氧气驱动雾化吸入氨溴索抑制双肺炎性反应的效果。方法健康家兔30只，随机分为3组（n=10）：双肺通气组（C组）、单肺通气组（OLV组）、氨溴索组（A组）。比较3组通气后双肺支气管肺泡灌洗液中TNFα、IL-1β、IL-8、IL-10浓度的变化。结果与C组比较， OLV组双侧肺灌洗液TNFα、IL-1β、IL-8浓度明显升高，IL-10浓度明显降低（P＜0.01）；左右肺比较，OLV组TNFα、IL-1β、IL-8浓度，左肺明显高于右肺，IL-10浓度明显低于右肺（P＜0.01）；与OLV组比较，A组双侧肺灌洗液TNFα、IL-1β、IL-8浓度均明显降低（P＜0.01），IL-10浓度明显升高（P＜0.01）。结论家兔OLV可诱发肺内炎性反应，而非通气侧肺内炎性反应程度明显高于通气侧肺；氧气驱动雾化吸入氨溴索可以明显减轻OLV所致双侧肺内炎性反应。
목적：비교단폐통기（OLV）후，가토쌍측폐내염성인자적변화，평개양기구동무화흡입안추색억제쌍폐염성반응적효과。방법건강가토30지，수궤분위3조（n=10）：쌍폐통기조（C조）、단폐통기조（OLV조）、안추색조（A조）。비교3조통기후쌍폐지기관폐포관세액중TNFα、IL-1β、IL-8、IL-10농도적변화。결과여C조비교， OLV조쌍측폐관세액TNFα、IL-1β、IL-8농도명현승고，IL-10농도명현강저（P＜0.01）；좌우폐비교，OLV조TNFα、IL-1β、IL-8농도，좌폐명현고우우폐，IL-10농도명현저우우폐（P＜0.01）；여OLV조비교，A조쌍측폐관세액TNFα、IL-1β、IL-8농도균명현강저（P＜0.01），IL-10농도명현승고（P＜0.01）。결론가토OLV가유발폐내염성반응，이비통기측폐내염성반응정도명현고우통기측폐；양기구동무화흡입안추색가이명현감경OLV소치쌍측폐내염성반응。
Objective To compare the effects of oxyge atomizing inhalation ambroxol on the inflammatory response to bilateral ventilatied lung undergoing one lung ventilation (OLV) in rabbit models. Methods Thirty healthy rabbits were randomly divided into 3 groups (n=10 each), control group (group C) received two-lung ventilation for two hours;group OLV received right-lung ventilation for two hours;group A received oxyge atomizing inhalation ambroxol 7.5mg before right-lung ventilation for two hours. Bilateral tracheal fluid concentrations of TNFα, IL-1β, IL-8, IL-10 were determined. Results Comparing to C group, Bilateral tracheal fluid concentrations of TNFα, IL-1β, IL-8 was significantly higher, IL-10 was significantly lower in OLV and A groups (P < 0.01). Comparing to right lung, The concentrations of TNFα, IL-1β, IL-8 were significantly higher and IL-10 was lower at left lung in OLV group (P< 0.01). Comparing to OLV group, Bilateral tracheal fluid concentrations of TNFα, IL-1β, IL-8 was significantly lower, IL-10 was significantly higher in A groups (P<0.01). Conclusion Inflammatory response could be provoked after OLV in rabbit, but non-ventilation lung were more severe than that of ventilation lung, oxyge atomizing inhalation ambroxol can inhibit the bilateral pulmonary inflammatory response.