当代化工
噹代化工
당대화공
CONTEMPORARY CHEMICAL INDUSTRY
2014年
3期
344-345
,共2页
刘广生%刘占龙%李德刚
劉廣生%劉佔龍%李德剛
류엄생%류점룡%리덕강
2-氯-4-三氟甲基吡啶%4-三氟甲基哌啶%4-(三氟甲基哌啶)盐酸盐
2-氯-4-三氟甲基吡啶%4-三氟甲基哌啶%4-(三氟甲基哌啶)鹽痠鹽
2-록-4-삼불갑기필정%4-삼불갑기고정%4-(삼불갑기고정)염산염
2-chloro-4-(trifluoromethyl)pyridine%4(trifluorom-ethyl)piperidine%4(trifluorom-ethyl)piperidine hy drochloride
以2-氯-4-三氟甲基吡啶为原料，两步加氢方法合成4-三氟甲基哌啶。研究了碱在加氢反应过程中的作用及其用量对加氢反应杂质的影响。对反应所用溶剂进行了筛选。当采用异丙醇为溶剂时，最终产品含量达到99.8%，产品收率＞80%。
以2-氯-4-三氟甲基吡啶為原料，兩步加氫方法閤成4-三氟甲基哌啶。研究瞭堿在加氫反應過程中的作用及其用量對加氫反應雜質的影響。對反應所用溶劑進行瞭篩選。噹採用異丙醇為溶劑時，最終產品含量達到99.8%，產品收率＞80%。
이2-록-4-삼불갑기필정위원료，량보가경방법합성4-삼불갑기고정。연구료감재가경반응과정중적작용급기용량대가경반응잡질적영향。대반응소용용제진행료사선。당채용이병순위용제시，최종산품함량체도99.8%，산품수솔＞80%。
4-(Trifluoromethyl)piperidine hydrochloride was prepared from 2-chloro-4- ( trifluoromethyl)pyridine by two-step hydrogenation method. The function of soda in the hydrogenation reaction was studied as well as effect of soda dosage on the product composition. Solvents in the reaction were screened. The purity of fin al product reached 99.8% and yield was more than 80% when isopropanol was used as solvent.
