中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2013年
19期
1-2
,共2页
加减瓜蒌薤白方酒剂%动脉粥样硬化%血脂%病理切片
加減瓜蔞薤白方酒劑%動脈粥樣硬化%血脂%病理切片
가감과루해백방주제%동맥죽양경화%혈지%병리절편
Gualou Xiebai recipe liquor agents%Atherosclerosis%Blood lipid%Pathological sections
目的：对加减瓜蒌薤白方酒剂在治疗大鼠动脉硬化实验中的相关数据进行分析，证实药物确切的疗效。方法：选取24月龄的健康大鼠60只，将其分为三组，20只/组。对其中两组大鼠采取VD3诱导、免疫损伤结合高脂喂养等方法建立大鼠动脉粥样硬化疾病模型。一组未处理组定为研究的对照组；一组仅进行疾病模型建立的为观察组；一组在建立疾病模型的基础上给予加减瓜蒌薤白方酒剂治疗，为治疗组。治疗45d后检测研究对象的血脂并进行主动脉、冠状动脉病理切片，就血总胆固醇、低密度脂蛋白、动脉壁蛋白聚糖组份硫酸软骨素、硫酸皮肤素含量等数据进行组间比较及统计学分析。结果：在血总胆固醇、低密度脂蛋白的比较中治疗组和观察组相似，无显著差异性（P>0.05）；且两组均显著高于对照组，且具有显著差异性（P<0.05）；在动脉壁蛋白聚糖组份硫酸软骨素、硫酸皮肤素含量比较中，治疗组与对照组相似，无显著差异性（P>0.05）；且两组均低于观察组，且具有显著差异性（P<0.05）。由此可知，治疗组大鼠动脉粥样硬化灶病变程度得到明显改善。结论：加减瓜蒌薤白方酒剂在24个月动脉粥样硬化大鼠的治疗中具有显著的疗效，为该方剂的研究及应用于临床提供数据支持。
目的：對加減瓜蔞薤白方酒劑在治療大鼠動脈硬化實驗中的相關數據進行分析，證實藥物確切的療效。方法：選取24月齡的健康大鼠60隻，將其分為三組，20隻/組。對其中兩組大鼠採取VD3誘導、免疫損傷結閤高脂餵養等方法建立大鼠動脈粥樣硬化疾病模型。一組未處理組定為研究的對照組；一組僅進行疾病模型建立的為觀察組；一組在建立疾病模型的基礎上給予加減瓜蔞薤白方酒劑治療，為治療組。治療45d後檢測研究對象的血脂併進行主動脈、冠狀動脈病理切片，就血總膽固醇、低密度脂蛋白、動脈壁蛋白聚糖組份硫痠軟骨素、硫痠皮膚素含量等數據進行組間比較及統計學分析。結果：在血總膽固醇、低密度脂蛋白的比較中治療組和觀察組相似，無顯著差異性（P>0.05）；且兩組均顯著高于對照組，且具有顯著差異性（P<0.05）；在動脈壁蛋白聚糖組份硫痠軟骨素、硫痠皮膚素含量比較中，治療組與對照組相似，無顯著差異性（P>0.05）；且兩組均低于觀察組，且具有顯著差異性（P<0.05）。由此可知，治療組大鼠動脈粥樣硬化竈病變程度得到明顯改善。結論：加減瓜蔞薤白方酒劑在24箇月動脈粥樣硬化大鼠的治療中具有顯著的療效，為該方劑的研究及應用于臨床提供數據支持。
목적：대가감과루해백방주제재치료대서동맥경화실험중적상관수거진행분석，증실약물학절적료효。방법：선취24월령적건강대서60지，장기분위삼조，20지/조。대기중량조대서채취VD3유도、면역손상결합고지위양등방법건립대서동맥죽양경화질병모형。일조미처리조정위연구적대조조；일조부진행질병모형건립적위관찰조；일조재건립질병모형적기출상급여가감과루해백방주제치료，위치료조。치료45d후검측연구대상적혈지병진행주동맥、관상동맥병리절편，취혈총담고순、저밀도지단백、동맥벽단백취당조빈류산연골소、류산피부소함량등수거진행조간비교급통계학분석。결과：재혈총담고순、저밀도지단백적비교중치료조화관찰조상사，무현저차이성（P>0.05）；차량조균현저고우대조조，차구유현저차이성（P<0.05）；재동맥벽단백취당조빈류산연골소、류산피부소함량비교중，치료조여대조조상사，무현저차이성（P>0.05）；차량조균저우관찰조，차구유현저차이성（P<0.05）。유차가지，치료조대서동맥죽양경화조병변정도득도명현개선。결론：가감과루해백방주제재24개월동맥죽양경화대서적치료중구유현저적료효，위해방제적연구급응용우림상제공수거지지。
Objective: To analyze the Gualou Xiebai recipe liquor agents in rat arterial sclerosis treatment related data in the experiment confirmed the efficacy of medicine, the exact. Methods:24 months 60 healthy rats, divided into three groups, 20 rats in each group. The two groups of rats induced by VD3, immune injury and high fat feeding method to establish the model of atherosclerotic disease in rats. A group of untreated control group for the study;a group of only disease model is established for the observation group;a group with modified Gualou Xiebai recipe liquor agents treatment based on disease model, as the treatment group. Treatment of 45 days of blood lipids research object and aorta, coronary artery pathological section, compared and statistical analysis on the data of blood total cholesterol, low density lipoprotein, arterial wall proteoglycans component chondroitin sulfate, dermatan sulfate content. Results: In comparison with serum total cholesterol, low density lipoprotein in treatment group and observation group, no significant difference (P>0.05);and the two group were significantly higher than that of the control group, with significant difference (P<0.05);in the aortic wall proteoglycans component chondroitin sulfate, dermatan sulfate content, the treatment group were similar to the control group, no significant difference (P>0.05);and the two group were lower than those in the observation group, with significant difference (P<0.05). Therefore, treatment of atherosclerotic lesions in rats of group is obviously improved. Conclusion: Gualou Xiebai recipe liquor agents has significant efficacy in the treatment of 24 months in atherosclerosis rats, for the research and application of the prescription and provide data support.
