CAJ | 학술논문

目的观察血清组蛋白去乙酰化酶3（HDAC3）水平与冠心病及冠状动脉狭窄程度之间的关系。方法165例患者分为冠状动脉造影正常组43例和冠心病组122例，再按Gensini冠状动脉积分分为3个亚组：轻度组54例，中度组42例和重度组26例；所有患者检测入院第2天清晨空腹血清 HDAC3水平。结果冠心病组血清HDAC3水平较冠状动脉造影正常组显著升高（P＜0.01）；冠状动脉狭窄轻度组、中度组、重度组三个亚组血清HDAC3水平比较差异无统计学意义（ P＞0.05）。结论 HDAC3应该被考虑作为一个新的冠心病危险因子，但其血清水平与冠状动脉狭窄程度无关。
목적관찰혈청조단백거을선화매3（HDAC3）수평여관심병급관상동맥협착정도지간적관계。방법165례환자분위관상동맥조영정상조43례화관심병조122례，재안Gensini관상동맥적분분위3개아조：경도조54례，중도조42례화중도조26례；소유환자검측입원제2천청신공복혈청 HDAC3수평。결과관심병조혈청HDAC3수평교관상동맥조영정상조현저승고（P＜0.01）；관상동맥협착경도조、중도조、중도조삼개아조혈청HDAC3수평비교차이무통계학의의（ P＞0.05）。결론 HDAC3응해피고필작위일개신적관심병위험인자，단기혈청수평여관상동맥협착정도무관。
Objective To observe the effect of serum histone deacetylase 3 (HDAC3) level on CHD and the severity of coronary artery stenosis .Methods A total of 165 patients were divided into two groups :non-CHD group( n=43)and CHD group( n=122) .According to Gensini method ,CHD group was divided into three sub-groups :mild group( n =54) ,moderate group( n=42) and severe group ( n=26);serum HDAC3 levels were de-tected at day 2 of admission in all patients .Results The serum HDAC3 level of CHD was significantly higher than that in non-CHD group ( P<0.01 );There was no significant difference between serum HDAC3 levels of the three CHD subgroups ( P >0.05 ) .Conclusion HDAC3 should be considered as a new risk factor of CHD ,but the serum HDAC3 level has no correlation with the severity of coronary artery stenosis .