CAJ | 학술논문

目的：探讨利多卡因对幼龄 SD 大鼠肠缺血-再灌注（I/R）肾脏的影响。方法：将80只4周龄 SD 大鼠随机分为假手术组（10只），肠缺血组（10只），肠缺血-再灌注组（30只）和利多卡因干预组（30只），后两组再灌注后0．5h 、1h 、2h 每个时间点分别处死10只动物。分别测定各组血 Scr 值，肾组织 MDA 含量和 MPO 活性，ICAM-1和 TNF-α表达。结果：利多卡因可降低肠缺血-再灌注幼龄 SD 大鼠 Scr 浓度和肾组织中 MDA 含量及 MPO 活性，下调肾组织中 ICAM-1和 TNF-α的表达（P＜0．05或0．01）。结论：利多卡因可减轻幼龄 SD 大鼠小肠 I/R 后肾损伤，其作用机制有待进一步研究。
목적：탐토리다잡인대유령 SD 대서장결혈-재관주（I/R）신장적영향。방법：장80지4주령 SD 대서수궤분위가수술조（10지），장결혈조（10지），장결혈-재관주조（30지）화리다잡인간예조（30지），후량조재관주후0．5h 、1h 、2h 매개시간점분별처사10지동물。분별측정각조혈 Scr 치，신조직 MDA 함량화 MPO 활성，ICAM-1화 TNF-α표체。결과：리다잡인가강저장결혈-재관주유령 SD 대서 Scr 농도화신조직중 MDA 함량급 MPO 활성，하조신조직중 ICAM-1화 TNF-α적표체（P＜0．05혹0．01）。결론：리다잡인가감경유령 SD 대서소장 I/R 후신손상，기작용궤제유대진일보연구。
Objective :To explore the effect of lidocaine on acute kidney injury induced by intestinal ischemia-reperfu-sion(I/R) in young rat .Methods :80 young SD rats at 4 weeks old were randomly assigned into sham operation(n= 10) , intestinal ischemia(n= 10) ,intestinal I/R(n= 30) and Lidocaine intervention groups(n= 30) ;in the last two groups ,10 animals were sacrificed at each time point of after reperfusion 0 .5 hour ,1 hour and 2 hours .The serum concentration of Cr and BUN were measured .Malondialdehyde (MDA ) ,myeloperoxidase (MPO ) and Tumor Necrosis Factor alpha (TNF-α) of renal tissue were detected .Results :Lidocaine decreased the levels of Scr ,MDA ,MPO ,and the renal expres-sion of ICAM-1 and TNF-α and (P< 0 .05 ,P< 0 .01) .Conclusion :Lidocaine might have a protective effect on ischemia /reperfusion-induced acute kidney injury .The mehcanism of it needs further study .