CAJ | 학술논문

目的探讨海洛因依赖者经美沙酮替代疗法后体液免疫功能变化的状况，以期指导临床治疗。方法将200例美沙酮替代疗法患者设为实验组，100例健康体检者设为对照组，比较实验组治疗半年前后，其体液免疫各指标（IgG、IgA、IgM、C3、C4）的差异；同时比较实验组治疗前后与对照组体液免疫各指标的差异。结果海洛因依赖者治疗前与对照组比较IgG、IgA、IgM均明显升高（P＜0．01），补体C3、C4均明显下降（P＜0．01）；经美沙酮替代疗法治疗后与治疗前比较，IgG 、IgA、IgM均明显下降（P＜0．01），补体C3、C4均明显升高（P＜0．01）；治疗后与对照组比较，IgA、C3、C4差异无统计学意义（P＞0．05），IgG、IgM 差异仍有统计学意义（P＜0．01）。结论对美沙酮替代疗法患者进行体液免疫指标的定期检测具有重要的临床指导意义。
목적탐토해락인의뢰자경미사동체대요법후체액면역공능변화적상황，이기지도림상치료。방법장200례미사동체대요법환자설위실험조，100례건강체검자설위대조조，비교실험조치료반년전후，기체액면역각지표（IgG、IgA、IgM、C3、C4）적차이；동시비교실험조치료전후여대조조체액면역각지표적차이。결과해락인의뢰자치료전여대조조비교IgG、IgA、IgM균명현승고（P＜0．01），보체C3、C4균명현하강（P＜0．01）；경미사동체대요법치료후여치료전비교，IgG 、IgA、IgM균명현하강（P＜0．01），보체C3、C4균명현승고（P＜0．01）；치료후여대조조비교，IgA、C3、C4차이무통계학의의（P＞0．05），IgG、IgM 차이잉유통계학의의（P＜0．01）。결론대미사동체대요법환자진행체액면역지표적정기검측구유중요적림상지도의의。
Objective To analyze the influence of methadone substitution treatment on humoral immunity in heroin addicts .Methods IgG ,IgA ,IgM ,C3 and C4 levels were detected in 200 heroin addicts before and after metha-done substitution treatment ,and 100 healthy subjects were enrolled and control group .Results Levels of IgG ,IgA and IgM were higher ,but those of C3 and C4 were lower in heroin addicts before treatment than healthy subjects (P<0 .01) .After treatment ,levels of IgG ,IgA and IgM significantly deceased ,and those of C3 and C4 increased (P<0 .01) .After treatment ,the difference of IgA ,C3 and C4 between heroin addicts and healthy subjects were not sig-nificant(P>0 .05) ,but the difference of IgG and IgM were still with significance (P<0 .01) .Conclusion Monitoring of humoral immunity could be with great significance in heroin addicts receiving methadone substitution treatment .