检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2013年
20期
2679-2680,2682
,共3页
慢性阻塞性肺疾病%肺动脉高压%法舒地尔%肿瘤坏死因子α%白细胞介素8%C反应蛋白
慢性阻塞性肺疾病%肺動脈高壓%法舒地爾%腫瘤壞死因子α%白細胞介素8%C反應蛋白
만성조새성폐질병%폐동맥고압%법서지이%종류배사인자α%백세포개소8%C반응단백
chronic obstructed pulmonary disease%pulmonary hypertension%fasudil%tumor necrosis fac-tor%interleukin-8%C reaction protein
目的探讨法舒地尔在治疗慢性阻塞性肺疾病（COPD）合并肺动脉高压中的作用机制。方法将68例合并肺动脉高压COPD加重期患者随机分为对照组与治疗组，每组34例。对照组给予常规治疗，治疗组在对照组基础上加用法舒地尔，疗程15 d。分别于治疗前后检测患者肺动脉压、血清肿瘤坏死因子（TNF-α）、白细胞介素8（IL-8）、C反应蛋白（CRP）水平。结果法舒地尔治疗后肺动脉压为（41．24±7．68）mmHg，低于对照组治疗后肺动脉压（49．56±4．02）mmHg，差异有统计学意义（P＜0．05）。法舒地尔治疗后炎性因子水平TNF-α（28．19±5．27）ng/L，IL-8（21．68±4．35）ng/L，CRP（40．79±1．97）mg/L，低于治疗前TNF-α（48．09±6．58）ng/L，IL-8（37．98±6．79）ng/L，CRP（71．36±3．21）mg/L，差异均有统计学意义（P＜0．05）。法舒地尔治疗组肺动脉压与TNF-α、IL-8、CRP水平呈正相关（P＜0．05）。结论法舒地尔治疗COPD合并肺动脉高压，可降低肺动脉压，降低炎性因子TNF-α、IL-8、CRP水平；肺动脉压及炎性因子有一定的相关性。
目的探討法舒地爾在治療慢性阻塞性肺疾病（COPD）閤併肺動脈高壓中的作用機製。方法將68例閤併肺動脈高壓COPD加重期患者隨機分為對照組與治療組，每組34例。對照組給予常規治療，治療組在對照組基礎上加用法舒地爾，療程15 d。分彆于治療前後檢測患者肺動脈壓、血清腫瘤壞死因子（TNF-α）、白細胞介素8（IL-8）、C反應蛋白（CRP）水平。結果法舒地爾治療後肺動脈壓為（41．24±7．68）mmHg，低于對照組治療後肺動脈壓（49．56±4．02）mmHg，差異有統計學意義（P＜0．05）。法舒地爾治療後炎性因子水平TNF-α（28．19±5．27）ng/L，IL-8（21．68±4．35）ng/L，CRP（40．79±1．97）mg/L，低于治療前TNF-α（48．09±6．58）ng/L，IL-8（37．98±6．79）ng/L，CRP（71．36±3．21）mg/L，差異均有統計學意義（P＜0．05）。法舒地爾治療組肺動脈壓與TNF-α、IL-8、CRP水平呈正相關（P＜0．05）。結論法舒地爾治療COPD閤併肺動脈高壓，可降低肺動脈壓，降低炎性因子TNF-α、IL-8、CRP水平；肺動脈壓及炎性因子有一定的相關性。
목적탐토법서지이재치료만성조새성폐질병（COPD）합병폐동맥고압중적작용궤제。방법장68례합병폐동맥고압COPD가중기환자수궤분위대조조여치료조，매조34례。대조조급여상규치료，치료조재대조조기출상가용법서지이，료정15 d。분별우치료전후검측환자폐동맥압、혈청종류배사인자（TNF-α）、백세포개소8（IL-8）、C반응단백（CRP）수평。결과법서지이치료후폐동맥압위（41．24±7．68）mmHg，저우대조조치료후폐동맥압（49．56±4．02）mmHg，차이유통계학의의（P＜0．05）。법서지이치료후염성인자수평TNF-α（28．19±5．27）ng/L，IL-8（21．68±4．35）ng/L，CRP（40．79±1．97）mg/L，저우치료전TNF-α（48．09±6．58）ng/L，IL-8（37．98±6．79）ng/L，CRP（71．36±3．21）mg/L，차이균유통계학의의（P＜0．05）。법서지이치료조폐동맥압여TNF-α、IL-8、CRP수평정정상관（P＜0．05）。결론법서지이치료COPD합병폐동맥고압，가강저폐동맥압，강저염성인자TNF-α、IL-8、CRP수평；폐동맥압급염성인자유일정적상관성。
Objective To investigate the function of fasudil in patients with chronic obstructive pulmonary dis-ease(COPD) with pulmonary hypertension .Methods Sixty-eight patients with COPD and pulmonary hypertension were randomly divided into control group ,receiving routine therapy ,and treatment group ,receivig routine therapy and fasudil treatment .Pulmonary pressure and serum tumor necrosis facto α(TNF-α) ,interleukin-8(IL-8) and C reaction protein(CRP) levels were detected before and after treatment .Results After treatment ,pulmonary pressure in treat-ment group was lower than control group(P<0 .05) .In treatment group ,serum levels of TNF-α,IL-8 and CRP were significantly decreased after treatment (P<0 .05) .Pulmonary pressure in treatment group was positively correlated with TNF-α,IL-8 and CRP level(P<0 .05) .Conclusion Treatment of fasudil in patients with COPD and pulmonary hypertension coud reduce pulmonary pressure and TNF-α,IL-8 ,CRP levels ,and pulmonary pressure might be corre-lated with inflammatory factors .
