国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
1期
3-5
,共3页
溃疡性结肠炎%黏膜屏障%膳食纤维%瘤坏死因子%内毒素
潰瘍性結腸炎%黏膜屏障%膳食纖維%瘤壞死因子%內毒素
궤양성결장염%점막병장%선식섬유%류배사인자%내독소
Ulcerative colitis%Mucosal barrier%Dietary fiber%Tumor necrosis factor%Endotoxin
目的 探讨添加复合膳食纤维的肠内营养对溃疡性结肠炎患者黏膜屏障功能的保护作用.方法 给予溃疡性结肠炎患者口服柳氮磺胺吡啶(SASP)1.0 g,4次/d,将治疗2周后病情未向重度转化的90例用随机数字表法分入三组行肠内营养治疗.C组:单纯能全素组；T1组:能全素+膳食纤维组(每500 kcal肠内营养液添加复合膳食纤维7.5 g,其中可溶性与不溶性膳食纤维1∶2)；T2组:能全素+膳食纤维组(每500 kcal肠内营养液添加复合膳食纤维7.5 g,其中可溶性与不溶性膳食纤维1∶3).分别于肠内营养治疗前及治疗7d后检测患者血浆中肿瘤坏死因子-α(TNF-α)及内毒素(endotoxin,ET)含量.结果 肠内营养治疗7d后,血浆中TNF-α浓度T1组[(144.5±20.0)ng/L]、T2组[(140.6±19.2)ng/L]明显低于C组[(170.7 ± 30.4)ng/L](P＜0.05),T1组与T2组间差异无统计学意义(P＞0.05)；血浆中ET浓度T1组[(0.137±0.018)Eu/ml]、T2组[(0.130±0.017) Eu/ml]明显低于C组[(0.156±0.012)Eu/ml](P＜0.05),T1组与T2组间差异无统计学意义(p＞0.05).结论 添加适量的复合膳食纤维的肠内营养可以降低肠黏膜的通透性,保护溃疡性结肠炎患者的肠黏膜屏障功能.
目的 探討添加複閤膳食纖維的腸內營養對潰瘍性結腸炎患者黏膜屏障功能的保護作用.方法 給予潰瘍性結腸炎患者口服柳氮磺胺吡啶(SASP)1.0 g,4次/d,將治療2週後病情未嚮重度轉化的90例用隨機數字錶法分入三組行腸內營養治療.C組:單純能全素組；T1組:能全素+膳食纖維組(每500 kcal腸內營養液添加複閤膳食纖維7.5 g,其中可溶性與不溶性膳食纖維1∶2)；T2組:能全素+膳食纖維組(每500 kcal腸內營養液添加複閤膳食纖維7.5 g,其中可溶性與不溶性膳食纖維1∶3).分彆于腸內營養治療前及治療7d後檢測患者血漿中腫瘤壞死因子-α(TNF-α)及內毒素(endotoxin,ET)含量.結果 腸內營養治療7d後,血漿中TNF-α濃度T1組[(144.5±20.0)ng/L]、T2組[(140.6±19.2)ng/L]明顯低于C組[(170.7 ± 30.4)ng/L](P＜0.05),T1組與T2組間差異無統計學意義(P＞0.05)；血漿中ET濃度T1組[(0.137±0.018)Eu/ml]、T2組[(0.130±0.017) Eu/ml]明顯低于C組[(0.156±0.012)Eu/ml](P＜0.05),T1組與T2組間差異無統計學意義(p＞0.05).結論 添加適量的複閤膳食纖維的腸內營養可以降低腸黏膜的通透性,保護潰瘍性結腸炎患者的腸黏膜屏障功能.
목적 탐토첨가복합선식섬유적장내영양대궤양성결장염환자점막병장공능적보호작용.방법 급여궤양성결장염환자구복류담광알필정(SASP)1.0 g,4차/d,장치료2주후병정미향중도전화적90례용수궤수자표법분입삼조행장내영양치료.C조:단순능전소조；T1조:능전소+선식섬유조(매500 kcal장내영양액첨가복합선식섬유7.5 g,기중가용성여불용성선식섬유1∶2)；T2조:능전소+선식섬유조(매500 kcal장내영양액첨가복합선식섬유7.5 g,기중가용성여불용성선식섬유1∶3).분별우장내영양치료전급치료7d후검측환자혈장중종류배사인자-α(TNF-α)급내독소(endotoxin,ET)함량.결과 장내영양치료7d후,혈장중TNF-α농도T1조[(144.5±20.0)ng/L]、T2조[(140.6±19.2)ng/L]명현저우C조[(170.7 ± 30.4)ng/L](P＜0.05),T1조여T2조간차이무통계학의의(P＞0.05)；혈장중ET농도T1조[(0.137±0.018)Eu/ml]、T2조[(0.130±0.017) Eu/ml]명현저우C조[(0.156±0.012)Eu/ml](P＜0.05),T1조여T2조간차이무통계학의의(p＞0.05).결론 첨가괄량적복합선식섬유적장내영양가이강저장점막적통투성,보호궤양성결장염환자적장점막병장공능.
Objective To explore the protective effect of enteral nutrition (EN) containing dietary fiber complex (DFC) in intestinal mucosal barrier function in patients with ulcerative colitis.Methods The patients with ulcerative colitis received sulfasalazine tablets of 1.0 g four times daily for two weeks.Then 90 of the patients whose symptoms did not become severe were randomly divided into three groups.Group C received no-DFC nutrition,while group T1 and T2 separately received EN with soluble dietary fiber or insoluble dietary fiber (every 500 kcal of EN with 7.5 g DFC) in certain proportion of 1 ∶ 3.Before and after a 7-day treatment,plasma concentrations of TNF-α and endotoxin (ET) were detected.Results 7 days after therapy with EN,concentration of TNF-α (144.5 ± 20.0) ng/L in group T1 and (140.6 ± 19.2) ng/L in group T2 was markedly lower than that in group C (170.7 ± 30.4) ng/L (P＜0.05),while the difference between groups T1 and T2 had no statistical significance (P＞0.05).Concentration of ET (0.137 ± 0.018) Eu/ml in group T1 or (0.130 ± 0.017) Eu/ml in group T2 was lower than that in group C (0.156 ± 0.012) Eu/ml (P＜0.05),and there was no statistical difference between groups T1 and T2 (P＞0.05).C onclusions Enteral nutrition containing proper amount of dietary fiber complex can reduce intestinal permeability and protect intestinal mucosal barrier function in patients with ulcerative colitis.
