中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
2期
257-259,260
,共4页
姜文英%吴雅枫%卓广超%王志华
薑文英%吳雅楓%卓廣超%王誌華
강문영%오아풍%탁엄초%왕지화
内脂素%细胞因子%C-反应蛋白%胎膜早破%绒毛膜羊膜炎
內脂素%細胞因子%C-反應蛋白%胎膜早破%絨毛膜羊膜炎
내지소%세포인자%C-반응단백%태막조파%융모막양막염
visfatin%cytokines%c-reaction protein ( CRP)%premature rupture of membranes%chorioamnionitis
目的：通过检测胎膜早破患者母血、脐血中内脂素、多项流式细胞因子及白细胞计数、C-反应蛋白（ CRP）的水平，探讨其在胎膜早破及宫内感染过程中可能的病理生理机制及相关意义。方法选择胎膜早破确诊宫内感染患者30例为研究组A；选取胎膜早破非宫内感染患者30例为阳性对照组B；另选取定期产检的正常孕妇30例为阴性对照组C，分析3组间胎膜早破与宫内感染的关系。结果研究组母血中白介素-6、白细胞、CRP、内脂素均明显高于对照组B（ t值分别为2．488、5．386、3．843、4．347，均P＜0．05）。母血CRP、白细胞、白介素-6及内脂素的曲线下面积（ AUC）分别为：0．819、0．830、0．753、0．784，与诊断宫内感染的金标准病理组织学诊断相比较，4个指标均在0．7～0．9之间，有一定的准确性。结论母血内脂素及白介素-6的检测对于预测胎膜早破患者宫内感染有重要意义。
目的：通過檢測胎膜早破患者母血、臍血中內脂素、多項流式細胞因子及白細胞計數、C-反應蛋白（ CRP）的水平，探討其在胎膜早破及宮內感染過程中可能的病理生理機製及相關意義。方法選擇胎膜早破確診宮內感染患者30例為研究組A；選取胎膜早破非宮內感染患者30例為暘性對照組B；另選取定期產檢的正常孕婦30例為陰性對照組C，分析3組間胎膜早破與宮內感染的關繫。結果研究組母血中白介素-6、白細胞、CRP、內脂素均明顯高于對照組B（ t值分彆為2．488、5．386、3．843、4．347，均P＜0．05）。母血CRP、白細胞、白介素-6及內脂素的麯線下麵積（ AUC）分彆為：0．819、0．830、0．753、0．784，與診斷宮內感染的金標準病理組織學診斷相比較，4箇指標均在0．7～0．9之間，有一定的準確性。結論母血內脂素及白介素-6的檢測對于預測胎膜早破患者宮內感染有重要意義。
목적：통과검측태막조파환자모혈、제혈중내지소、다항류식세포인자급백세포계수、C-반응단백（ CRP）적수평，탐토기재태막조파급궁내감염과정중가능적병리생리궤제급상관의의。방법선택태막조파학진궁내감염환자30례위연구조A；선취태막조파비궁내감염환자30례위양성대조조B；령선취정기산검적정상잉부30례위음성대조조C，분석3조간태막조파여궁내감염적관계。결과연구조모혈중백개소-6、백세포、CRP、내지소균명현고우대조조B（ t치분별위2．488、5．386、3．843、4．347，균P＜0．05）。모혈CRP、백세포、백개소-6급내지소적곡선하면적（ AUC）분별위：0．819、0．830、0．753、0．784，여진단궁내감염적금표준병리조직학진단상비교，4개지표균재0．7～0．9지간，유일정적준학성。결론모혈내지소급백개소-6적검측대우예측태막조파환자궁내감염유중요의의。
Objective To probe into the possible pathophysiological mechanism and significance of visfatin , flow cell factors , white blood cell counts and C reactive protein ( CRP) level in premature rupture of fetal membranes and intrauterine infection by detecting their levels in maternal and umbilical cord blood .Methods Thirty cases of premature rupture of membranes with diagnosed intrauterine infection were selected in study group A , 30 cases of premature rupture of membranes without intrauterine infection were selected in positive control group B, and 30 cases of normal pregnant women taking regular check up were selected in negative control group C .The relationship between premature rupture of membranes and intrauterine infection in these 3 groups was analyzed.Results Interleukin-6 (IL-6), white blood cell, CRP and visfatin in maternal blood in study group A were significantly higher than those in control group B ( t value was 2.488, 5.386, 3.843 and 4.347, respectively, all P<0.05).Area under curve (AUC) of maternal serum CRP, white blood cells, IL-6 and visfatin was 0.819, 0.830, 0.753 and 0.784, respectively.When they were compared with the histopathological diagnosis , the gold standard in diagnosis of intrauterine infection , these four values were between 0.7-0.9, which had certain accuracy .Conclusion The detection of visfatin and IL-6 in maternal blood is important in predicting intrauterine infection in patients with premature rupture of membranes .
