中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
25期
352-354
,共3页
多黏菌素E%60Co照射%甲磺酸乙酯%发酵
多黏菌素E%60Co照射%甲磺痠乙酯%髮酵
다점균소E%60Co조사%갑광산을지%발효
Polymyxin E%60Co irradiation%EMS%Fermentation
以多黏芽胞杆菌（Bacillus polymyxa）090918为出发菌株，经60Co-r射线照射（剂量为22Gy）、甲磺酸乙酯（EMS）诱变处理、多黏菌素E耐受等处理，得到一株多黏菌素E突变株120116，其摇瓶发酵效价较出发菌株提高26%。
以多黏芽胞桿菌（Bacillus polymyxa）090918為齣髮菌株，經60Co-r射線照射（劑量為22Gy）、甲磺痠乙酯（EMS）誘變處理、多黏菌素E耐受等處理，得到一株多黏菌素E突變株120116，其搖瓶髮酵效價較齣髮菌株提高26%。
이다점아포간균（Bacillus polymyxa）090918위출발균주，경60Co-r사선조사（제량위22Gy）、갑광산을지（EMS）유변처리、다점균소E내수등처리，득도일주다점균소E돌변주120116，기요병발효효개교출발균주제고26%。
As Bacillus polymyxa 090918 for starting strain, A streptomyces aureofaciens mutant 120116 with the productivity increased by 26%was obtained by compound treatments such as irradiation with 60Co (the dosage of 22Gy) radiation, Ethyl methyl sulfonic acid (EMS) mutagenesis, Polymyxin E tolerance etc.
