CAJ | 학술논문

目的探讨缓解期克罗恩病患者血清25-羟基维生素D与炎性细胞因子白细胞介素-10（interleukin-10，IL-10）及肿瘤坏死因子-α（tumour necrosis factor-α，TNF-α）的关系。方法根据血清维生素D水平将35例缓解期克罗恩病患者分为维生素D缺乏组（A组）和维生素D充足组（B组），采用ELISA检测两组患者入组时及A组患者经补充维生素D治疗后的血清IL-10和TNF-α水平。结果 A、B两组患者血清TNF-α水平比较无统计学差异（P＞0.05），A组患者血清IL-10水平显著低于B组（P＜0.05）；A组患者经补充维生素D治疗后血清IL-10和TNF-α水平与治疗前比较无统计学差异（P＞0.05）。结论存在维生素D缺乏的克罗恩病患者循环IL-10水平显著降低，提示维生素D缺乏可能与这些患者的抗炎能力下降有关。
목적탐토완해기극라은병환자혈청25-간기유생소D여염성세포인자백세포개소-10（interleukin-10，IL-10）급종류배사인자-α（tumour necrosis factor-α，TNF-α）적관계。방법근거혈청유생소D수평장35례완해기극라은병환자분위유생소D결핍조（A조）화유생소D충족조（B조），채용ELISA검측량조환자입조시급A조환자경보충유생소D치료후적혈청IL-10화TNF-α수평。결과 A、B량조환자혈청TNF-α수평비교무통계학차이（P＞0.05），A조환자혈청IL-10수평현저저우B조（P＜0.05）；A조환자경보충유생소D치료후혈청IL-10화TNF-α수평여치료전비교무통계학차이（P＞0.05）。결론존재유생소D결핍적극라은병환자순배IL-10수평현저강저，제시유생소D결핍가능여저사환자적항염능력하강유관。
Objective To determine if serum 25-hydroxy-vitamin D was associated with inflammatory cytokines, interleukin-10 (IL-10), and tumour necrosis factor-α(TNF-α) levels in patients with inactive Crohn’s disease (CD). Methods 35 adults with quiescent CD were divided into vitamin D-insufifcient group (group A) and vitamin D-replete group (group B) according to serum 25-hydroxy-vitamin D levels. Then serum IL-10 and TNF-αlevel were detected by ELISA and compared. After vitamin D supplement to patients in group A, serum IL-10 and TNF-αlevels were detected again and compared to previous levels. Result Serum IL-10 levels of patients in group A were signiifcantly lower compared with group B (P<0.05) while there were no differences in serum TNF-αlevels (P>0.05). The use of a vitamin D supplement did not signiifcantly inlfuence serum IL-10 and TNF-αlevel (P>0.05). Conclusions Circulating levels of IL-10, but not TNF-alpha, were signiifcantly lower in CD patients with inadequate serum 25-hydroxy-vitamin D. This suggests that poor vitamin D status may be linked to reduced anti-inlfammatory capacity in these patients.