CAJ | 학술논문

目的探讨超敏C反应蛋白（hs-CRP）及血清胱抑素C（CysC）在2型糖尿病（T2DM）早期肾损伤诊断中的应用价值。方法根据尿肾功能指标（包括尿微量白蛋白（mAlb）、血清肌酐（SCr））把130例T2DM患者分为尿、肾功能正常组及尿、肾功能异常组各65例。并选择同期65例健康查体者做对照组。分别测定3组CysC、hs-CRP、Cr及尿mAlb水平。结果2型糖尿病患者hs-CRP及CysC的水平高于对照组，尿肾功异常组显著高于尿肾功正常组，且hs-CRP和CysC水平呈正相关。结论 hs-CRP及CysC可作为糖尿病肾病早期诊断的灵敏指标，联合检测更具有临床实用价值。
목적탐토초민C반응단백（hs-CRP）급혈청광억소C（CysC）재2형당뇨병（T2DM）조기신손상진단중적응용개치。방법근거뇨신공능지표（포괄뇨미량백단백（mAlb）、혈청기항（SCr））파130례T2DM환자분위뇨、신공능정상조급뇨、신공능이상조각65례。병선택동기65례건강사체자주대조조。분별측정3조CysC、hs-CRP、Cr급뇨mAlb수평。결과2형당뇨병환자hs-CRP급CysC적수평고우대조조，뇨신공이상조현저고우뇨신공정상조，차hs-CRP화CysC수평정정상관。결론 hs-CRP급CysC가작위당뇨병신병조기진단적령민지표，연합검측경구유림상실용개치。
Objective To explore the clinical diagnostic value of the Combined measuring of high sensitivity C-reactive protein and serum cystatin C in type 2 diabetic mellitus(T2DM)patients with early renal injury. Methods According to urine renal function indice(including urinary microalbumin and serum creatinine),130 patients with T2DM were divided into Two groups:urine renal function normal group(n=65) and urine renal function abnormal group(n=65). 65 healthy patients were served as control group. The levels of serum hs-CRP, Cys C, Cr and urinary malb were measured. Results The levels of serum hs-CRP and Cys C in patients with T2DM were higher than those in control group(P<0.01);while the levels of serum hs-CRP and Cys C in urine renal function abnormal group were signiifcantly increased than those in urine renal function normal group(P<0.01).Hs-CRP was positively correlated with serum Cys C.Conclusion Hs-CRP and Cys C can be used as sensitive indice of diagnosing early renal damage in type2 diabetic mellitus.Combined measuring had more practical value.