CAJ | 학술논문

目的比较阿立哌唑与利培酮治疗精神分裂症患者的疗效、不良反应及生活质量的影响。方法对68例精神分裂症患者，随机分为两组，每组34例，分别给予阿立哌唑与利培酮治疗8周，采用阳性与阴性症状量表（PANSS）评定疗效，治疗中出现的症状量表（TESS）评定不良反应，以生活质量综合评定问卷（GQOLI-74）评定生活质量。结果两组均有显著疗效，阿立哌唑与利培酮均可显著提高生活质量。两组疗效比较差异无统计学意义（P>0.05）；阿立哌唑不良反应61.8%，利培酮70.6%，两组差异无统计学意义（P>0.05）。结论阿立哌唑与利培酮治疗精神分裂症疗效相当，不良反应小，均可提高患者生活质量。
목적비교아립고서여리배동치료정신분렬증환자적료효、불량반응급생활질량적영향。방법대68례정신분렬증환자，수궤분위량조，매조34례，분별급여아립고서여리배동치료8주，채용양성여음성증상량표（PANSS）평정료효，치료중출현적증상량표（TESS）평정불량반응，이생활질량종합평정문권（GQOLI-74）평정생활질량。결과량조균유현저료효，아립고서여리배동균가현저제고생활질량。량조료효비교차이무통계학의의（P>0.05）；아립고서불량반응61.8%，리배동70.6%，량조차이무통계학의의（P>0.05）。결론아립고서여리배동치료정신분렬증료효상당，불량반응소，균가제고환자생활질량。
Objective:To investigate the efficacy and side effects and quality of life in schizophrenic patients treated by aripiprazole and risperidone.Methods:A total of 68 patients schizophrenia were randomly divided into aripiprazole group(n=34) and risperidone group(n=34) for 8 weeks treatment.Positive and Negative Symptoms Scale(PANSS) was used to evaluate the clinical efficacy,Treatment Emergent Symptom Scale(TESS) for side effects and General Quality Of Life Inventory (GQOLI-74) for quality of life.Results The patients in both groups had significant clinical efficacy,and the two drugs obviously improved the quality of life. There were no significant difference in two groups(p>0.05).The side effects in the aripiprazole group were 61.8%and 70.6% in the risperidone group. There were no significant difference in two groups(p>0.05).Conclusion Aripiprazole and risperidone are similar in the treatment of schizophrenia with fewer side effects,and they both improve quality of life.