中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2013年
26期
85-86
,共2页
段静娴%孙素姣%王燕%马琼
段靜嫻%孫素姣%王燕%馬瓊
단정한%손소교%왕연%마경
强脉冲光%黄褐斑%谷胱甘肽%随机对照实验
彊脈遲光%黃褐斑%穀胱甘肽%隨機對照實驗
강맥충광%황갈반%곡광감태%수궤대조실험
intense pulsed light%melasma%reduced glutathione%randomized controlled trial
目的探讨强脉冲光(intense pulsed light IPL)联合还原型谷胱甘肽治疗黄褐斑的疗效及安全性。方法采用12周随机、对照实验,90位受试者随机分为实验组、对照1组和对照2组,实验组及对照1组接受3次IPL治疗,实验组术后联合静脉滴注还原型谷胱甘肽辅助治疗,对照2组仅行静滴谷胱甘肽治疗。通过研究者评价治疗前、后黄褐斑面积变化进行功效评估,并由患者进行满意度评估。结果经过治疗,实验组91.7%的患者获得了超过50%的改善,83.3%的患者对治疗效果满意或非常满意,且肤质改善明显,仅有1例(2.8%)复发,副作用主要为轻微的一过性红斑;对照1组有6例﹙21.4%﹚复发,5例(17.9%)出现轻-中度色素沉着,对照2组有10例(38.5%)复发。结论强脉冲光联合静滴还原型谷胱甘肽可以有效地治疗黄褐斑,临床疗效明显优于对照组。
目的探討彊脈遲光(intense pulsed light IPL)聯閤還原型穀胱甘肽治療黃褐斑的療效及安全性。方法採用12週隨機、對照實驗,90位受試者隨機分為實驗組、對照1組和對照2組,實驗組及對照1組接受3次IPL治療,實驗組術後聯閤靜脈滴註還原型穀胱甘肽輔助治療,對照2組僅行靜滴穀胱甘肽治療。通過研究者評價治療前、後黃褐斑麵積變化進行功效評估,併由患者進行滿意度評估。結果經過治療,實驗組91.7%的患者穫得瞭超過50%的改善,83.3%的患者對治療效果滿意或非常滿意,且膚質改善明顯,僅有1例(2.8%)複髮,副作用主要為輕微的一過性紅斑;對照1組有6例﹙21.4%﹚複髮,5例(17.9%)齣現輕-中度色素沉著,對照2組有10例(38.5%)複髮。結論彊脈遲光聯閤靜滴還原型穀胱甘肽可以有效地治療黃褐斑,臨床療效明顯優于對照組。
목적탐토강맥충광(intense pulsed light IPL)연합환원형곡광감태치료황갈반적료효급안전성。방법채용12주수궤、대조실험,90위수시자수궤분위실험조、대조1조화대조2조,실험조급대조1조접수3차IPL치료,실험조술후연합정맥적주환원형곡광감태보조치료,대조2조부행정적곡광감태치료。통과연구자평개치료전、후황갈반면적변화진행공효평고,병유환자진행만의도평고。결과경과치료,실험조91.7%적환자획득료초과50%적개선,83.3%적환자대치료효과만의혹비상만의,차부질개선명현,부유1례(2.8%)복발,부작용주요위경미적일과성홍반;대조1조유6례﹙21.4%﹚복발,5례(17.9%)출현경-중도색소침착,대조2조유10례(38.5%)복발。결론강맥충광연합정적환원형곡광감태가이유효지치료황갈반,림상료효명현우우대조조。
Objective: To investigate the long - term efficacy and safety of intense pulsed light (IPL) and reduced glutathione device in the treatment of melasma lesions. Methods: A randomized、controlled 12 weeks study was conducted. Ninety patients were randomly divided into the treatment group、the control group1 and the control group2.The treatment group and the control group1 received three IPL treatments, and the treatment group were injected with reduced glutathione. The control group2 were injected with reduced glutathione only. The results were observed before and after each session respectively. The efficacy was evaluated using a percentage category scale, and a satisfaction scale. Results:By the end of the study, the treatment group (91.7%) obtained 50% improvements, according to the over-all evaluation by dermatologists,83.3% patients considered their results satisfactory or very satisfactory, and their skin quality was better than before obviously, adverse reactions were mainly transient erythema, only 1 case (2.8%) recurrence; there were 6 patients (21.4%) recurrence, 5 patients (17.9%) of post-inflammatory hyperpigmentation(PIH) in the control group1, 10 patients (38.5%) recurrence in control group2. Conclusion: The study demonstrates that IPL combined with reduced glutathione is a good option for patients with melasma, the clinical efficacy is superior to the control group.