CAJ | 학술논문

目的观察偏头痛急性发作期患者血浆溶血磷脂酸(LPA)及溶血磷脂酸相似磷脂水平(AP)、经颅多普勒超声（TCD）的变化。方法测定偏头痛急性期患者（无先兆偏头痛组及有先兆偏头痛组）血浆LPA及AP水平，同时对患者行TCD检查，与正常患者进行对照。结果偏头痛组血浆LPA水平高于对照组，尤其是有先兆偏头痛组，且偏头痛急性期TCD以血流速度增快为主，尤其是患侧大脑中动脉血流速度。结论偏头痛发作期患者LPA、AP明显升高，尤其是有先兆偏头痛组升高更明显，提示偏头痛急性发作期患者存在血小板活化过程，同时偏头痛急性期患者血流速度常明显增快，支持偏头痛患者存在神经-血管功能紊乱。
목적관찰편두통급성발작기환자혈장용혈린지산(LPA)급용혈린지산상사린지수평(AP)、경로다보륵초성（TCD）적변화。방법측정편두통급성기환자（무선조편두통조급유선조편두통조）혈장LPA급AP수평，동시대환자행TCD검사，여정상환자진행대조。결과편두통조혈장LPA수평고우대조조，우기시유선조편두통조，차편두통급성기TCD이혈류속도증쾌위주，우기시환측대뇌중동맥혈류속도。결론편두통발작기환자LPA、AP명현승고，우기시유선조편두통조승고경명현，제시편두통급성발작기환자존재혈소판활화과정，동시편두통급성기환자혈류속도상명현증쾌，지지편두통환자존재신경-혈관공능문란。
Objective Observation the changesof plasma lysophosphatidic acid (LPA) 、lysophosphatidic acid similar levels of phospholipids(AP) and Transcranial Doppler ultrasound (TCD) in acute migraine patients. Methodes Determination plasma LPA and AP in migraine patients with acute period (migraine without aura and migraine with aura group) ,at the same time,were examined by TCD, compared with normal patients. Results Migraine patients with LPA 、AP increased significantly, especial y for migraine with aura group increased more significantly, suggesting that platelet activation in patients with acute migraine attacks, and blood flow velocity in patients with migraine acute stage significantly increased in patients with migraine.The results support functions - vascular nerve disorder in patients with migraine.