CAJ | 학술논문

目的：探讨恩替卡韦联合复方鳖甲软肝片治疗肝硬化的疗效。方法：对2010年7月-2011年7月本院治疗乙型肝炎肝硬化（代偿期）的88例患者进行研究，将其按病历号码分为治疗组和对照组，每组各44例。对照组采用恩替卡韦进行基础治疗，治疗组在此基础上加用复方鳖甲软肝片治疗，所有患者均连续治疗1年。治疗1年后，对比两组患者在肝功能改善情况方面的差异。结果：治疗前，两组在肝功能指标以及肝纤维化指标方面比较差异无统计学意义（P>0.05）。治疗1年后，治疗组有效率高于对照组；肝功能指标中治疗组ALT和TBIL下降更明显，PTA和Alb上升更高；两组患者的血清肝纤维化指标均明显下降，但治疗组下降更明显；两组以上指标比较差异具有统计学意义（P<0.05）。结论：恩替卡韦联合复方鳖甲软肝片治疗肝硬化代偿期患者，临床症状改善明显，肝纤维化程度降低，可显著改善患者的生存质量。
목적：탐토은체잡위연합복방별갑연간편치료간경화적료효。방법：대2010년7월-2011년7월본원치료을형간염간경화（대상기）적88례환자진행연구，장기안병력호마분위치료조화대조조，매조각44례。대조조채용은체잡위진행기출치료，치료조재차기출상가용복방별갑연간편치료，소유환자균련속치료1년。치료1년후，대비량조환자재간공능개선정황방면적차이。결과：치료전，량조재간공능지표이급간섬유화지표방면비교차이무통계학의의（P>0.05）。치료1년후，치료조유효솔고우대조조；간공능지표중치료조ALT화TBIL하강경명현，PTA화Alb상승경고；량조환자적혈청간섬유화지표균명현하강，단치료조하강경명현；량조이상지표비교차이구유통계학의의（P<0.05）。결론：은체잡위연합복방별갑연간편치료간경화대상기환자，림상증상개선명현，간섬유화정도강저，가현저개선환자적생존질량。
Objective:To analyze the effect of combined application entecavir and Bie Jiarangan pill in the treatment of cirrhosis. Method:88 patients with cirrhosis were divided into objective group and the control group. The combined application entecavir and Bie Jiarangan pill were used in the objective,and the control used the entecavir only. The difference of improvement situation of liver function between the two groups were compared after one years.Result:The objective group got the better clinical effect;The ALT and TBIL reduced more and the PTA and Alb grew more in the objective group than that in the control group;Two groups of patients’ serum liver fibrosis indexes decreased obviously,but the treatment group decreased more obvious;These indicators had statistical significance between the two groups(P<0.05). Conclusion:It get a satisfactory effect to combined application entecavir and Bie Jiarangan pill in the treatment of cirrhosis,with better clinical effect and liver function.