CAJ | 학술논문

目的探讨妊娠糖尿病(GDM)血清钙的变化与胰岛素抵抗(IR)的关系.方法选取40例GDM患者以及42例正常糖耐量(NGT)孕妇,测定其血清钠、钾、钙、空腹血糖(FBG)及空腹胰岛素(FNS),并计算胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI),统计比较数据并相关分析.结果 GDM组HOMA-IR较NGT组升高,ISI较NGT组降低,经t检验,P<0.05,差异有统计学意义.相关分析显示,GDM患者血清钙离子水平与HOMA-IR呈负相关(P<0.05),与ISI呈正相关(P<0.05).结论 GDM患者存在钙离子代谢紊乱,血清钙降低,会引起细胞内钙离子浓度升高,从而加重IR.对指导临床治疗有重要意义.
목적탐토임신당뇨병(GDM)혈청개적변화여이도소저항(IR)적관계.방법선취40례GDM환자이급42례정상당내량(NGT)잉부,측정기혈청납、갑、개、공복혈당(FBG)급공복이도소(FNS),병계산이도소저항지수(HOMA-IR)、이도소민감지수(ISI),통계비교수거병상관분석.결과 GDM조HOMA-IR교NGT조승고,ISI교NGT조강저,경t검험,P<0.05,차이유통계학의의.상관분석현시,GDM환자혈청개리자수평여HOMA-IR정부상관(P<0.05),여ISI정정상관(P<0.05).결론 GDM환자존재개리자대사문란,혈청개강저,회인기세포내개리자농도승고,종이가중IR.대지도림상치료유중요의의.
Objective This research is to investigate the correlation between serum calcium and IR in GDM patients. Methods Serum calcium levels were determined together with serum Na+, K+, FBG, FINS. These parameters were classified and matched statistically. The serum calcium, HOMA-IR, ISI of experimental group and control group were compared. The correlation between serum calcium and HOMA-IR, ISI was analyzed. Results The levels of HOMA-IR for the experimental group were significantly higher than that of the control group, and the levels of ISI were lower. Both were analyzed with the test (P<0.05).The significant inverse correlation of serum calcium with HOMA-IR (P<0.05) as well as significant positive correlation of serum calcium with ISI were seen (P<0.05). Conclusions Abnormal calcium metabolism with lower serum calcium levels, which would cause higher intracellular calcium concentration, is responsible for IR, which will be important for clinical treatment.