CAJ | 학술논문

目的初步探讨弥散张量成像(diffusion tensor imaging,DTI)对前列腺癌(prostate carcinoma,PCa)和前列腺增生(benign prostate hyperplasia,BPH)的诊断及鉴别诊断价值.方法分别对40例前列腺患者及3O名健康志愿者进行前列腺DTI扫描,并将原始图像传送至西门子Leonardo工作站,采用DTI专用软件进行分析处理.记录感兴趣区的各向异性比值(fractionalanisotropy FA)、平均ADC值.绘制FA和平均ADC表格,分析PCa癌灶、BPH增生结节、正常中央带及外周带的各向异性值(fractional anisotropy,FA值)和平均表观弥散系数(apparent diffusion coefficient,ADC值)的变化特点进行比较,最终分别计算三组的平均值范围,并绘制DTI参数图.结果 PCa、BPH、正常中央带及外周带的FA值依次降低,分别为(0.294±0.075)、(O.252±0.054)、(0.215±0.033)和(0.130±0.022),四者有显著统计学差异(P=0.000).PCa、BPH、正常中央带及正常外周带的ADC值依次增高,分别为(0.902±0.408)×10-3mm2/s、(1.267±0.201)×10-3mm2/s、(1.405±0.164)×10-3mm2/s和(1.771±0.281)×10-3mm2/s,四者有显著统计学差异(P=0.000).结论 DTI能够提供前列腺的组织微观结构信息,有助于前列腺疾病的诊断及鉴别.
목적초보탐토미산장량성상(diffusion tensor imaging,DTI)대전렬선암(prostate carcinoma,PCa)화전렬선증생(benign prostate hyperplasia,BPH)적진단급감별진단개치.방법분별대40례전렬선환자급3O명건강지원자진행전렬선DTI소묘,병장원시도상전송지서문자Leonardo공작참,채용DTI전용연건진행분석처리.기록감흥취구적각향이성비치(fractionalanisotropy FA)、평균ADC치.회제FA화평균ADC표격,분석PCa암조、BPH증생결절、정상중앙대급외주대적각향이성치(fractional anisotropy,FA치)화평균표관미산계수(apparent diffusion coefficient,ADC치)적변화특점진행비교,최종분별계산삼조적평균치범위,병회제DTI삼수도.결과 PCa、BPH、정상중앙대급외주대적FA치의차강저,분별위(0.294±0.075)、(O.252±0.054)、(0.215±0.033)화(0.130±0.022),사자유현저통계학차이(P=0.000).PCa、BPH、정상중앙대급정상외주대적ADC치의차증고,분별위(0.902±0.408)×10-3mm2/s、(1.267±0.201)×10-3mm2/s、(1.405±0.164)×10-3mm2/s화(1.771±0.281)×10-3mm2/s,사자유현저통계학차이(P=0.000).결론 DTI능구제공전렬선적조직미관결구신식,유조우전렬선질병적진단급감별.
Objective To explore diffusion tensor imaging (DTI) for prostate cancer (PCa) and benign prostatic hyperplasia (BPH) in the diagnosis and differential diagnosis value. Methods 40 cases respectively on patients with prostate and 30 healthy olunteers for prostate DTI scan, and the original image is transmitted to the Siemens Leonardo workstation. Records of the area of interest anisotropic ratio (FA), average ADC values. analysis PCa carcinoma stove, BPH hyperplastic nodule, normal central belt and peripheral zone anisotropic value (FA) and average apparent dispersion coefficient ( ADC) the change features of comparison, finally calculated the average of the three groups range, and draw DTI parameter map. Results PCa, BPH, normal central belt and peripheral zone of the FA value in turn reduce, respectively (0.294± 0.075), (0.252 ±0.054), (0.215 ± 0.033) and (0.130± 0.022), four person have statistically significant difference (P = 0.000). PCa, BPH, normal central belt and normal peripheral zone of ADC values in turn increase, respectively (0.902 ± 0.408)×10-3 best callus induction/s,(1.267 ± 0.201)×10-3 best callus induction/s,(1.405 ± 0.164)×10-3 best callus induction/s and (1.771 ± 0.281 ×10-3 best callus induction/s, four person have statistically significant difference (P = 0.000). Conclusion DTI can provide prostate tissue microstructure information, help the prostate disease diagnosis and identification.