CAJ | 학술논문

目的评价放射性核素153钐-乙二胺四甲撑酸(153Sm-EDTMP)治疗恶性肿瘤骨转移的疗效和对外周血象的影响.方法用153Sm-EDTMP对196例骨转移病人进行内照射治疗,剂量(29.6~37.0)MBq/公斤体重(0.8~1.0mci/kg),治疗前先抽血,主要查白细胞、血小板、红细胞及血红蛋白.治疗后观察骨痛,血清碱性磷酸酶(ALP),血细胞及病灶的变化,并于治疗后2周及部分病人3个月各抽外周血同上化验项目.结果196例病人有164例(83.7%)骨痛缓解,随访35例病人有13例(37.1%)病人骨转移灶钙化或消除；治疗后2周病人末梢血白细胞、血小板、红细胞和血红蛋白与治疗前均有显著降低(t=8.19,7.39,5.00,4.15,P<0.01)；而在三个月时随访的108例病人上述检查项目基本恢复.结论153Sm-EDTMP对转移性骨肿瘤有明显的缓解骨痛,控制病情进展和消除病灶的作用；同时有降血细胞、红细胞和血红蛋白的副作用,但是是可逆的.
목적평개방사성핵소153삼-을이알사갑탱산(153Sm-EDTMP)치료악성종류골전이적료효화대외주혈상적영향.방법용153Sm-EDTMP대196례골전이병인진행내조사치료,제량(29.6~37.0)MBq/공근체중(0.8~1.0mci/kg),치료전선추혈,주요사백세포、혈소판、홍세포급혈홍단백.치료후관찰골통,혈청감성린산매(ALP),혈세포급병조적변화,병우치료후2주급부분병인3개월각추외주혈동상화험항목.결과196례병인유164례(83.7%)골통완해,수방35례병인유13례(37.1%)병인골전이조개화혹소제；치료후2주병인말소혈백세포、혈소판、홍세포화혈홍단백여치료전균유현저강저(t=8.19,7.39,5.00,4.15,P<0.01)；이재삼개월시수방적108례병인상술검사항목기본회복.결론153Sm-EDTMP대전이성골종류유명현적완해골통,공제병정진전화소제병조적작용；동시유강혈세포、홍세포화혈홍단백적부작용,단시시가역적.
Objective To evaluate the radionuclide 153 Sm - Ethylene Diamine Tetra stays acid (153Sm-EDTMP) to treat malignant tumors of osseous metastasis as the efficacy and the impact of peripheral blood; Methods 153Sm-EDTMP on 196 cases of patients with bone metastasis irradiation therapy, the dose (29.6 ~ 37.0) MBq / kg body weight (0.8 ~1.0mci/kg), before treatment haemospasia, the main check leucocyte, platelets, akaryocyte and hemoglobin. Post-treatment to observe bone paint, serum alkaline phosphatase (ALP), blood cells and changes in the lesion and in the treatment of patients after 2 weeks and 3 months of haemospasia Ibid laboratory test items. Results 196 patients with 164 patients (83.7%), pain mitigation, follow-up of 35 cases of patients in 13 cases (37.1%) patients with bone metastases calcified or eliminate;2 weeks after treatment the patient peripheral blood leukocytes, platelets, akaryocyte and hemoglobin and before treatment were significantly lower (t = 8.19,7.39,5.00,4.15, P <0.01); while the three-month follow-up of 108 patients when the above-mentioned inspection items of basic restoration; Conclusion 153Sm-EDTMP for metastatic tumors of bone apparent ease pain, control disease progression and the elimination of the role of lesion; simultaneously lowering blood cells, akaryocyte and hemoglobin side effects, but it is reversible.