CAJ | 학술논문

目的探讨冠心病患者血清瘦素、脂联素及超敏炎症C-反应蛋白(Hs-CRP)的表达水平及相关性。方法选择心绞痛62人、心肌梗死40人、健康对照组35人，分别测定三组血清瘦素、脂联素及Hs-CRP的水平，分析同时分析三者之间与冠心病高危因素的关系。结果在对照组、心绞痛组及心肌梗死组之间，瘦素及Hs-CRP呈递增趋势，而脂联素呈递减趋势，各组件差异具有统计学意义。同时，分析得出在冠心病患者中，瘦素与脂联素之间呈负相关，瘦素与Hs-CRP、WHR呈正相关关系，而脂联素与Hs-CRP、WHR之间呈负相关。结论血清高瘦素、低脂联素水平可能参与了冠心病的发生及发展，检测瘦素及脂联素水平对于临床评估冠心病的进展有一定的参考价值。
목적탐토관심병환자혈청수소、지련소급초민염증C-반응단백(Hs-CRP)적표체수평급상관성。방법선택심교통62인、심기경사40인、건강대조조35인，분별측정삼조혈청수소、지련소급Hs-CRP적수평，분석동시분석삼자지간여관심병고위인소적관계。결과재대조조、심교통조급심기경사조지간，수소급Hs-CRP정체증추세，이지련소정체감추세，각조건차이구유통계학의의。동시，분석득출재관심병환자중，수소여지련소지간정부상관，수소여Hs-CRP、WHR정정상관관계，이지련소여Hs-CRP、WHR지간정부상관。결론혈청고수소、저지련소수평가능삼여료관심병적발생급발전，검측수소급지련소수평대우림상평고관심병적진전유일정적삼고개치。
Objective To study the expression and relastionship about serum leptin,adiponectin and Hs-CRP in coronary artery disease. Methods 62 patients with angina were involved, 40 with myocardial infarction and 35 were control group. The expression and the relationship of serum leptin, adiponectin and Hs-CRP were detected. Results in the control group, angina and myocardial infarction, leptin and Hs-CRP increased, while adiponectin decresed; there was significant diffidence in each component. In patients with angina, a negative correlation existed between serum leptin and adiponectin, a positive correlation between leptin and Hs-CRP, WHR, while a negative correlation existed between adiponectin and Hs-CRP, WHR. Conclusion high serum leptin and low adiponectin leves may were of great clinical importance.