中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2013年
5期
6-7
,共2页
黑色素性神经鞘瘤%临床病理%免疫组织化学
黑色素性神經鞘瘤%臨床病理%免疫組織化學
흑색소성신경초류%림상병리%면역조직화학
Melanotic schwannoma%Clinicopathology%Immunohistochemistry
目的探讨黑色素性神经鞘瘤的临床病理学特点。方法通过1例肋骨黑色素性神经鞘瘤的临床病理、免疫组织化学特点的观察和随访，并结合文献综合分析。结果肿瘤大小2cm×2cm×2cm，浸润肋骨周围横纹肌，为多边形上皮样和短梭形细胞混合，成片排列，少量色素仅见于个别细胞，细胞核圆形或卵圆形，无浓染和染色质增粗，无核分裂，肿瘤中血管周淋巴细胞呈袖套样浸润，免疫组化示Vimentin（+++），S-100(++),HMB-45个别细胞（+），GFAP(++)，Ki-67(1%+)，随访40个月无复发和/或转移。结论黑色素性神经鞘瘤少见，可无色素,可浸润性生长，生物学行为潜在恶性，需长期随访。
目的探討黑色素性神經鞘瘤的臨床病理學特點。方法通過1例肋骨黑色素性神經鞘瘤的臨床病理、免疫組織化學特點的觀察和隨訪，併結閤文獻綜閤分析。結果腫瘤大小2cm×2cm×2cm，浸潤肋骨週圍橫紋肌，為多邊形上皮樣和短梭形細胞混閤，成片排列，少量色素僅見于箇彆細胞，細胞覈圓形或卵圓形，無濃染和染色質增粗，無覈分裂，腫瘤中血管週淋巴細胞呈袖套樣浸潤，免疫組化示Vimentin（+++），S-100(++),HMB-45箇彆細胞（+），GFAP(++)，Ki-67(1%+)，隨訪40箇月無複髮和/或轉移。結論黑色素性神經鞘瘤少見，可無色素,可浸潤性生長，生物學行為潛在噁性，需長期隨訪。
목적탐토흑색소성신경초류적림상병이학특점。방법통과1례륵골흑색소성신경초류적림상병리、면역조직화학특점적관찰화수방，병결합문헌종합분석。결과종류대소2cm×2cm×2cm，침윤륵골주위횡문기，위다변형상피양화단사형세포혼합，성편배렬，소량색소부견우개별세포，세포핵원형혹란원형，무농염화염색질증조，무핵분렬，종류중혈관주림파세포정수투양침윤，면역조화시Vimentin（+++），S-100(++),HMB-45개별세포（+），GFAP(++)，Ki-67(1%+)，수방40개월무복발화/혹전이。결론흑색소성신경초류소견，가무색소,가침윤성생장，생물학행위잠재악성，수장기수방。
Objective To study clinicopathological feature of the melanotic schwannoma. Method A melanotic schwannoma case of rib was investigated in clinicopathological and immunohistochemical feature, follow-up and literature review. Result The diameter of the tumor was 2cm and the muscle of the rib was infiltrated. Histological examination showed the tumor mixing with polygonal and plump spindle cell arranged in sheet. Rare pigment was seen in the rare cell, The tumor cell showed round and oval nuclear, no nuclear mitoses and hyperchromatin. lymphocyties was senn in vascular in the tumor.Vimentin,S-100 protein,HMB-45,GFAP were immunohistochemically stained.Ki-67 was 1% positive . The patient was followed in 40 months, and was no finding recurring and/or metastasis. Conclusion Melanotic schwannoma is a rare tumor and it is sometimes no pigment and infiltrating, Bilogically it is potential malignant and requires long-term follow-up.
