CAJ | 학술논문

目的：探讨理气开郁法中药板块方的镇痛作用特点。方法：将150只清洁级昆明种小鼠，按体重随机区组法分为15组，包括对照组，柴郁汤、芍甘汤、痛泻要方、金铃子散高中低剂量各组，吗啡和布洛芬组，采用45℃、50℃、55℃水浴引致小鼠疼痛模型，动态测定痛阈潜伏期，用药前测定基础痛阈。采用重复测量设计的方差分析。结果：柴郁汤、芍甘汤和痛泻要方的镇痛作用以高剂量更明显；柴郁汤对45℃、50℃、55℃水浴的痛阈潜伏期均有延长作用，柴郁汤高、中剂量在多个时间点上显示出较好的镇痛作用。结论：柴郁汤的镇痛作用较强，作用特点类似于中枢镇痛药或兼有中枢性镇痛作用；芍药甘草汤、痛泻药方、金铃子散属于作用于外周的镇痛药。
목적：탐토리기개욱법중약판괴방적진통작용특점。방법：장150지청길급곤명충소서，안체중수궤구조법분위15조，포괄대조조，시욱탕、작감탕、통사요방、금령자산고중저제량각조，마배화포락분조，채용45℃、50℃、55℃수욕인치소서동통모형，동태측정통역잠복기，용약전측정기출통역。채용중복측량설계적방차분석。결과：시욱탕、작감탕화통사요방적진통작용이고제량경명현；시욱탕대45℃、50℃、55℃수욕적통역잠복기균유연장작용，시욱탕고、중제량재다개시간점상현시출교호적진통작용。결론：시욱탕적진통작용교강，작용특점유사우중추진통약혹겸유중추성진통작용；작약감초탕、통사약방、금령자산속우작용우외주적진통약。
Objective To investigate the characterstics of the analgesic effect of regulating Qi and alleviat-ing mental depression prescriptions. Methods One hundred and fifty Kunming mice of clean grade, according to randomized blocks by body weight, were divided into 15 groups, including non-treatment model control group (control group), high, middle and low dose groups of Chaiyu decotion(柴郁汤), Shaogan decoction(芍甘汤), Tongxie(痛泻) prescription and Jinlingzi(金铃子) powder, positive control drug Morphine and Ibuprofen groups. A rat pain model was made using tail-immersion in 45 ℃, 50 ℃, 55 ℃ water to induce pain. The pain threshold latency was measured dynamically, measuring the base pain threshold before administration. Analysis of variance of repeated measure definition was applied. Results The analgesic effect of Chaiyu decotion(柴郁汤), Shaogan decoction(芍甘汤)and Tongxie(痛泻)prescription of high doses was more obvious. Pain thresh-old latency was prolonged by Chaiyu decotion(柴郁汤)in tail-immersion test of 45 ℃, 50 ℃, 55 ℃(P<0.01, P<0.05), the high and middle doses of Chaiyu decotion(柴郁汤)demonstrated good analgesic effect at multi-ple time points (P<0.05). Conclusion Chaiyu decotion(柴郁汤) has strong analgesic effect, similar to the role of central analgesic drugs; Shaogan decoction(芍甘汤), Tongxie(痛泻)prescription and Jinlingzi(金铃子) powder belong to the peripheral analgesic drugs such as NSAIDs.