CAJ | 학술논문

锌指核酸酶(zinc finger nuclease,ZFNs)和转录激活因子样效应物核酸酶(transcription activator-like effector nucleases,TALENs)技术是基因靶向修饰的重要方法,为各大领域尤其是遗传疾病的基因治疗带来广阔的前景.该文对ZFNs与TALENs的作用机制、应用领域和局限性进行比较,为基因修饰研究工作的开展提供参考.
자지핵산매(zinc finger nuclease,ZFNs)화전록격활인자양효응물핵산매(transcription activator-like effector nucleases,TALENs)기술시기인파향수식적중요방법,위각대영역우기시유전질병적기인치료대래엄활적전경.해문대ZFNs여TALENs적작용궤제、응용영역화국한성진행비교,위기인수식연구공작적개전제공삼고.
The technologies using Zinc finger nuclease (ZFNs) and transcription activator-like effector nucleases (TALENs) are important methods for genetic modification,and show great potentials in many fields,especially for the therapies of genetic diseases.In this paper,we compared ZFNs and TALENs from several aspects,including the mechanisms,application fields and limitations,and provide some data and comments which are to be useful for the research work of genetic modification.